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Anxiety and Mood Changes
Some people report mood changes, depression, and anxiety with Depo-Provera, although the evidence is inconsistent.
In clinical trials, 10.8% of users reported nervousness, and 1.5% reported depression.
If you have a history of depression, it’s important to monitor for mood-related side effects while using Depo-Provera. If you experience symptoms of depression, consider discontinuing use.