Liu W, Ren Y, Wang T, Wang M, Xu Y, Zhang J, et al. Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells. Cell Death Discov. 2024;10:156.
Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16:175–84.
Lu Y, Li B, Wei M, Zhu Q, Gao L, Ma N, et al. HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis. Int Immunopharmacol. 2023;125:110950.
Wang X, Qian J, Meng Y, Wang P, Cheng R, Zhou G, et al. Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways. Heliyon. 2023;9:e13225.
Gao L, Dong X, Gong W, Huang W, Xue J, Zhu Q, et al. Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis. Br J Pharm. 2021;178:3533–52.
Al Mamun A, Suchi SA, Aziz MA, Zaeem M, Munir F, Wu Y, et al. Pyroptosis in acute pancreatitis and its therapeutic regulation. Apoptosis. 2022;27:465–81.
Yang J, Tang X, Wu Q, Ren P, Yan Y, Liu W, et al. Heparin protects severe acute pancreatitis by inhibiting HMGB-1 active secretion from macrophages. Polymers (Basel). 2022;14:2470.
Altinkaya E, Aktas A. Insulin and heparin therapies in acute pancreatitis due to hypertriglyceridemia. J Coll Physicians Surg Pak. 2021;31:1337–40.
Song Y, Wu Y, Ding F, Li S, Shen Y, Yang B, et al. The preventive and therapeutic effects of acute and severe inflammatory disorders with heparin and heparinoid. Biomolecules. 2024;14:1078.
Singh KK, Gupta A, Forstner D, Guettler J, Ahrens MS, Prakasan Sheeja A, et al. LMWH prevents thromboinflammation in the placenta via HBEGF-AKT signaling. Blood Adv. 2024;8:4756–66.
Yang R, Zhang X. A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 activation. Front Cell Infect Microbiol. 2022;12:984835.
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, et al. KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. Nat Commun. 2016;7:13227.
Zeng J, Chen JY, Meng J, Chen Z. Inflammation and DNA methylation coregulate the CtBP-PCAF-c-MYC transcriptional complex to activate the expression of a long non-coding RNA CASC2 in acute pancreatitis. Int J Biol Sci. 2020;16:2116–30.
Buczek-Thomas JA, Hsia E, Rich CB, Foster JA, Nugent MA. Inhibition of histone acetyltransferase by glycosaminoglycans. J Cell Biochem. 2008;105:108–20.
Li Y, Guo X, Hu C, Du Y, Guo C, Di W, et al. Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death Differ. 2018;25:1304–18.
Li X, Liang Q, Liu L, Chen S, Li Y, Pu Y. FTO attenuates TNF-α-induced damage of proximal tubular epithelial cells in acute pancreatitis-induced acute kidney injury via targeting AQP3 in an N6-methyladenosine-dependent manner. Ren Fail. 2024;46:2322037.
Zhou F, Li D, Liu C, Li C, Li K, Shi L, et al. m6A-activated BACH1 exacerbates ferroptosis by epigenetic suppression HSPB1 in severe acute pancreatitis. Drug Dev Res. 2024;85:e22256.
Chen F, Su M, Han D, Wang Y, Song M. METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1. Int Immunopharmacol. 2024;128:111495.
Yang K, Zhong Z, Zou J, Liao JY, Chen S, Zhou S, et al. Glycolysis and tumor progression promoted by the m(6)A writer VIRMA via m(6)A-dependent upregulation of STRA6 in pancreatic ductal adenocarcinoma. Cancer Lett. 2024;590:216840.
Ouyang C, Xu G, Xie J, Xie Y, Zhou Y. Silencing of KIAA1429, a N6-methyladenine methyltransferase, inhibits the progression of colon adenocarcinoma via blocking the hypoxia-inducible factor 1 signalling pathway. J Biochem Mol Toxicol. 2024;38:e23829.
Song Y, Zhang Z, Yu Z, Xia G, Wang Y, Wang L, et al. Wip1 aggravates the caerulein-induced cell autophagy and inflammatory injury by targeting STING/TBK1/IRF3 in acute pancreatitis. Inflammation. 2021;44:1175–83.
Baron TH, DiMaio CJ, Wang AY, Morgan KA. American gastroenterological association clinical practice update: management of pancreatic necrosis. Gastroenterology. 2020;158:67–75.e1.
Fonseca Sepúlveda EV, Guerrero-Lozano R. Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. J Pediatr (Rio J). 2019;95:713–9.
Beurskens DMH, Huckriede JP, Schrijver R, Hemker HC, Reutelingsperger CP, Nicolaes GAF. The anticoagulant and nonanticoagulant properties of heparin. Thromb Haemost. 2020;120:1371–83.
Podda M, Murzi V, Marongiu P, Di Martino M, De Simone B, Jayant K, et al. Effectiveness and safety of low molecular weight heparin in the management of acute pancreatitis: a systematic review and meta-analysis. World J Emerg Surg. 2024;19:30.
Zhou L, Chen J, Mu G, Lu Z, Li W, Deng Y. Heparin-binding protein (HBP) worsens the severity of pancreatic necrosis via up-regulated M1 macrophages activation in acute pancreatitis mouse models. Bioengineered. 2021;12:11978–86.
Ma N, Yuan C, Shi J, Zhu Q, Liu Y, Ma X, et al. Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis. JCI Insight. 2022;7:e161244.
Sun B, Chen Z, Chi Q, Zhang Y, Gao B. Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP). J Cell Mol Med. 2021;25:10441–53.
Peng Y, Yang Y, Li Y, Shi T, Xu N, Liu R, et al. Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis. Cell Mol Biol Lett. 2024;29:61.
Chen L, Kraft BD, Roggli VL, Healy ZR, Woods CW, Tsalik EL, et al. Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia. Am J Physiol Lung Cell Mol Physiol. 2021;321:L321–35.
Lv Z, Ran R, Yang Y, Xiang M, Su H, Huang J. The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms. Discov Oncol. 2023;14:78.
Zhang T, Zhu S, Huang GW. ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis. World J Gastroenterol. 2024;30:1764–76.
Zhang T, Sheng P, Jiang Y. m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma. J Cancer Res Clin Oncol. 2023;149:2805–22.
Peng W, Furuuchi N, Aslanukova L, Huang YH, Brown SZ, Jiang W, et al. Elevated HuR in pancreas promotes a pancreatitis-like inflammatory microenvironment that facilitates tumor development. Mol Cell Biol. 2018;38.
Zhou W, Wang X, Yan B, Sun Y. Embryonic lethal abnormal visual-like protein 1 aggravates caerulein-induced AR42J cell injury and macrophage M1 polarization to accelerate acute pancreatitis by upregulating TRAF6. J Interferon Cytokine Res. 2025;40:20–28.
Sun YJ, Chen HY, Lai XQ. ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein. Kaohsiung J Med Sci. 2025;41:e12911.
Dent SYR. KAT tales: functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC. J Biol Chem. 2024;300:107744.
Hu Y, Dai J, Zong G, Xiao J, Guo X, Dai Y, et al. Restoration of p53 acetylation by HDAC inhibition permits the necrosis/apoptosis switch of pancreatic ainar cell during experimental pancreatitis in mice. J Cell Physiol. 2019;234:21988–98.
Zhou Q, Tao X, Guo F, Wu Y, Deng D, Lv L, et al. Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases. BMC Med. 2023;21:329.
Mishra A, Chanchal S, Ashraf MZ. Host-viral interactions revealed among shared transcriptomics signatures of ARDS and thrombosis: a clue into COVID-19 pathogenesis. TH Open. 2020;4:e403–e12.
Bruno V, Amati F, Ticconi C, Riccio S, Vancheri C, Rizzacasa B, et al. Low molecular weight heparin -induced miRNA changes in peripheral blood mononuclear cells in pregnancies with unexplained recurrent pregnancy loss. J Reprod Immunol. 2022;151:103502.
Leppaniemi A, Tolonen M, Tarasconi A, Segovia-Lohse H, Gamberini E, Kirkpatrick AW, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019;14:27.