CAR T-cells targeting CD117 effectively eliminate mast cells in preclinical models of advanced systemic mastocytosis

Hoermann G, Sotlar K, Jawhar M, Kristensen T, Bachelot G, Nedoszytko B, et al. Standards ...

The TCR in CAR T cell therapy: use it or lose it?

Goyco Vera D, Waghela H, Nuh M, Pan J, Lulla P. Approved CAR-T therapies have ...

DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling

Cells and ethics The cell lines were purchased from ATCC (Manassas, VA) and cultured in ...

Progress in the development of cytokine armoured CAR T cells

Fuchs, T. L. et al. Assessment of tumor-infiltrating lymphocytes using International TILs Working Group (ITWG) ...

Modulating AP-1 enables CAR T cells to establish an intratumoral stemlike reservoir and overcomes resistance to PD-1 blockade | Science Immunology

c-Jun overexpression fails to prevent CAR T cell exhaustion in tumors, but PD-L1 blockade restores ...

Lung tumouroids as a testing platform for precision CAR T cell therapy

Patient samples The study was performed in accordance with the Declaration of Helsinki. Written informed ...

BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

Mice Male and female C57BL/6J (B6, strain 000664), B6.SJL-Ptprca Pepcb/BoyJ (B6 CD45.1, strain 002014) and ...

BACH2 regulates T cell lineage state to enhance CAR T cell function

Frigault, M. J. et al. Identification of chimeric antigen receptors that mediate constitutive or inducible ...

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial

Oversight The MG-001 part 3 trial was performed in accordance with the principles of the ...

CAR T-cells in multiple myeloma: the race to the start line

Marit G, Boiron JM, Reiffers J. Autologous blood stem cell transplantation in high risk myeloma. ...