SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses

Despite the achievements of immunotherapy in the treatment of cancer, overcoming the immune resistance is ...

DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

Xue G, Li X, Kalim M, Fang J, Jiang Z, Zheng N, et al. Clinical ...

Hematopoietic expression of cIAP2 drives inflammation and heart failure after myocardial infarction

Human samples Patient samples (blood whole plasma, peripheral blood mononuclear cells (PBMCs) and whole unfractionated ...

Mitoxantrone alters CD24/Siglec-10 expression in malignant brain tumor models

CD24 is associated with genes predicting prognosis in brain tumors Understanding CD24-tumor heterogeneity is crucial ...

The co-delivery of Programmed Death 1 ligands enhances and prolongs rAAV-mediated gene expression in pre-immunized mice

Plasmids and viral vectors PD-L1-P2A-VEGF-B186 and VEGF-B186-P2A-PD-L1 constructs, with and without codon optimization, were synthesized ...

Potential of plant chloroplast-based recombinant expression systems to express bacterial membrane proteins as vaccine candidates for Salmonella in poultry

Construct design and cloning The nucleotide sequences of CirA, FepA, FhuA, and IroN derived from ...

Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells

Mosquito production Mosquitoes from a colony of Anopheles stephensi (line Nijmegen SDA500) were used to ...