Goblet cells tune ILC2 activity through a gut-specific response checkpoint | Science Immunology

Notch signaling tunes the environmental responsiveness of intestinal ILC2s. ...

In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Science Immunology

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming. ...

Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species | Science Immunology

Quenching mitochondrial reactive oxygen species in monocyte-derived macrophages, but not in microglia, ameliorates neuroinflammation. ...

B cells gone broad: A deep dive into SARS-CoV-2 antibody breadth | Science Immunology

Antigen-specific B cell profiling uncovers key determinants of SARS-CoV-2 antibody breadth after infection and vaccination. ...

Foxp3: The epigenetic engineer of regulatory T cell identity | Science Immunology

The Foxp3 transcription factor integrates cell-intrinsic and environmental contexts with epigenetic programs to establish regulatory ...

A parasite partner for regulatory affairs | Science Immunology

Targeting Treg cells to mitigate inflammation has been a challenge, but a parasite-derived cytokine may ...

Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function | Science Immunology

Foxp3 integrates cell-intrinsic and environmental contexts with epigenetic programs to establish Treg cell molecular identity ...

Citraconate preserves T cell stemness and antitumor immunity | Science Immunology

Citraconate preserves stemness, mitigates ferroptosis, and potentiates T cell antitumor immunity by modulating the PDE1-cAMP-ALOX5 ...

Immune mechanisms of congenital Zika syndrome | Science Immunology

This Review discusses both fetal and maternal immune responses that influence the development of congenital ...

Macrophages restrict tumor immune infiltration by controlling collagen topography | Science Immunology

In solid tumors, local fibrillar collagen topography is imposed by macrophages and dictates T cell ...