Tag: Inhibition

Naringin alleviates periodontitis via direct AMPK/Nrf2 activation and NLRP3 inhibition, amplified by gut microbiota/Arg-Gln modulation

Naringin alleviates periodontitis via direct AMPK/Nrf2 activation and NLRP3 inhibition, amplified by gut microbiota/Arg-Gln modulation

Periodontitis, driven by oral-gut microbiota dysbiosis and NLRP3 inflammasome activation, lacks effective natural therapeutic strategies. ...

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DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

Xue G, Li X, Kalim M, Fang J, Jiang Z, Zheng N, et al. Clinical ...

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CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off

CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off

Reck, M., Remon, J. & Hellmann, M. D. First-line immunotherapy for non-small-cell lung cancer. J. ...

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Inhibition of cGAS in dendritic cells suppresses maturation and prolongs allograft survival in mice

Inhibition of cGAS in dendritic cells suppresses maturation and prolongs allograft survival in mice

Durand F, Levitsky J, Cauchy F, Gilgenkrantz H, Soubrane O, Francoz C. Age and liver ...

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Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells

Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells

Bach, J. F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. ...

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Targeted innate immune inhibition therapy compared with antibiotics for recurrent acute cystitis: a randomized, open-label phase 2 trial

Targeted innate immune inhibition therapy compared with antibiotics for recurrent acute cystitis: a randomized, open-label phase 2 trial

Study design For this randomized, open-label, single-centre, phase 2 trial, patients were enrolled at the ...

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PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

Klebanoff, C. A. et al. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established ...

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Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy

Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy

Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M. & Reis, E. S. ...

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Pre-activation timing determines influenza severity and viral pathogenicity via STING Inhibition

Pre-activation timing determines influenza severity and viral pathogenicity via STING Inhibition

Cell culture and pre-activation Murine B16-F10 melanoma cells (B16 cells) and human A549 lung adenocarcinoma ...

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