LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity

The success of therapeutic cancer vaccines hinges on overcoming the immunosuppressive tumor microenvironment (TME) and ...

Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment

Human participants Sepsis patients and controls were recruited at Tianjin Medical University General Hospital. Sepsis ...

Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes

Mice and cell line Rnf213 knockout (Rnf213–/–, KO) mice on a C57BL/6 background were generously ...

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen | Science Immunology

Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust ...

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history

Assembly of a large dataset of paired T cell repertoires and HLA allotypes Given that ...

Damage-induced pyroptosis drives endogenous thymic regeneration by activating the purinergic receptor P2Y2

Kinsella S, Dudakov JA. When the damage is done: injury and repair in thymus function. ...

A T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia

Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis ...

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity

Ribas, A. et al. SD-101 in combination with pembrolizumab in advanced melanoma: results of a ...

Study design The study design for the DESIRES trial has been previously reported (NCT04274257)30. The ...