Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. ...

In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Science Immunology

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming. ...

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma

Mapping the spatiocellular principles of lymphoma-induced LN remodeling To decipher the overarching principles that govern ...

Reprogramming the immune orchestra for glioblastoma: oncolytic viruses and the B-cell connection

Glioblastoma multiforme (GBM) is a lethal primary brain cancer for which treatment has limited options, ...

Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist

Hopfner KP, Hornung V. Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol ...

STING controls glycolysis and histone lactylation to drive macrophage metabolic reprogramming in postoperative ileus

Vather, R., Trivedi, S. & Bissett, I. Defining postoperative ileus: results of a systematic review ...

PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

Klebanoff, C. A. et al. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established ...

Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia | Science Immunology

SFB colonization phenotypically alters alveolar macrophages, maintaining their antibacterial functions in inflamed interferon-rich lungs. ...