CD70/CD27 signaling promotes the pathogenesis of multiple myeloma and represents a promising therapeutic target

Vogelsberg A, Schürch CM, Fend F. Multiples Myelom aus Sicht der Pathologie. Radiologe. 2022;62:12–19. Article  ...

DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling

Cells and ethics The cell lines were purchased from ATCC (Manassas, VA) and cultured in ...

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis

Human samples and animals Human DRG samples listed in Supplementary Table 8 were included in ...

High-salt diet aggravates allergic rhinitis through the NFAT5 signaling pathway

Wang, X. et al. The traditional Chinese medicine and non-small cell lung cancer: from a ...

RETN exacerbates sepsis by GBP5/NLRP3 signaling pathway-mediated pyroptosis of macrophage

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The ...

Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes

Mice and cell line Rnf213 knockout (Rnf213–/–, KO) mice on a C57BL/6 background were generously ...

Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Human donors BM samples were obtained from three independent cohorts, each used for distinct analyses. ...

STAT1 signaling controls cholesterol metabolism in epithelial cells and RSV-induced syncytia formation

Biallelic Knockout of STAT1 alters cellular cholesterol metabolism and homeostasis For the generation of a ...

Obesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling

Czech MP. Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 2017;23:804–14. ...

Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling

Enhanced CD8+ T cell proliferation after temporal cell cycle inhibition To uncouple CD8+ T cell ...