Tag: stemness

Citraconate preserves T cell stemness and antitumor immunity | Science Immunology

Citraconate preserves T cell stemness and antitumor immunity | Science Immunology

Citraconate preserves stemness, mitigates ferroptosis, and potentiates T cell antitumor immunity by modulating the PDE1-cAMP-ALOX5 ...

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BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

Mice Male and female C57BL/6J (B6, strain 000664), B6.SJL-Ptprca Pepcb/BoyJ (B6 CD45.1, strain 002014) and ...

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Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

BACH2 overexpression locks T cells in a quiescent ineffective state We and others have shown ...

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Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. Selective expression of ...

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