We Asked a Doctor How Magnesium Interacts With Common Sleep Aids

Magnesium has become a popular supplement among those trying to improve their sleep, but is it safe to use with other over-the-counter sleep aids?

We asked Harneet Walia, MD, the medical director of sleep at the Miami Cardiac and Vascular Institute, to find out.

Q: Are magnesium supplements safe to take with other common sleep aids such as Unisom, Benadryl, or NyQuil? What about melatonin?

Walia: Using several sedating products together can cause more drowsiness, dizziness, or tiredness the next day. This can be dangerous, especially when you’re driving.

Medications like Unisom, Benadryl, and NyQuil have antihistamines, and they’re already quite sedating, so taking them with magnesium could strengthen these effects.

While some supplements contain both magnesium and melatonin, research is lacking on their combined effectiveness. It is also possible that combining them could lead to side effects such as increased drowsiness.

It’s safest to use just one sleep aid at a time. Start with the lowest dose that works, and avoid mixing different products unless a healthcare provider recommends it.

Should I Stick to Magnesium On Its Own?

There is limited evidence that magnesium helps with sleep; only a few small studies have shown any benefit. While most people can use magnesium safely, it’s not entirely without risks. Magnesium supplement isn’t regulated by the FDA, and it can make the sedative effects of other substances stronger.

High doses may cause an upset stomach or diarrhea and may interact with certain medications. People with kidney or liver issues, or those on drugs affecting magnesium levels, should be cautious. It’s best to consult your doctor before adding magnesium to your routine.

So, What Should I Do for Poor Sleep?

Rather than simply adding more supplements or medications, addressing the underlying causes of poor sleep is crucial.

Healthy sleep habits, such as keeping a regular schedule, minimizing evening screen time, and following a relaxing bedtime routine, are the key to better sleep. It is essential to know that cognitive behavioral therapy for sleep is the mainstay of treatment for someone with insomnia.