Which Is Better for Energy, Heart Health, and Sleep?

Which Is Better for Energy, Heart Health, and Sleep?

Key Takeaways

  • Caffeinated coffee is more likely than decaffeinated coffee to help you feel alert, energetic, and stronger, but also to interfere with your sleep and cause nervousness and jitteriness. 
  • Caffeinated coffee and decaffeinated coffee are both associated with a lower risk of metabolic syndrome and type 2 diabetes.
  • Caffeinated coffee can help prevent weight gain, and decaffeinated coffee is more effective at reducing high blood pressure.

Coffee can affect your health in many ways, including preventing you from getting enough sleep, making you jittery, and preventing excessive weight gain. Differences in how caffeinated coffee and decaffeinated coffee affect your health, and the benefits and drawbacks of each, depend on your own health.

1. Energy, Alertness, and Strength

Caffeine can increase alertness, energy, and physical abilities.

Common effects include:

  • Feeling more awake
  • Moving faster
  • Improved athletic ability
  • Stronger muscle strength

Caffeinated coffee has a more significant impact on these factors than decaffeinated coffee.  

What’s the Difference in Caffeine?

Coffee naturally has caffeine. Decaffeinated versions are produced through a chemical process that lowers the caffeine content.

Caffeine content of a 12-ounce coffee (1.5 cup):

  • Caffeinated coffee: 113 to 247 milligrams (mg) caffeine
  • Decaffeinated coffee: 3 to 22 mg caffeine

2. Sleep

Caffeine can interfere with your sleep for hours after you consume it. In general, the effects last between four and 12 hours, but could wear off sooner or last longer for some people.

How coffee affects your sleep:

  • Caffeinated or decaffeinated: You may need to get up to use the toilet.
  • Caffeinated: More sleep disruption, can cause racing thoughts and tossing and turning in bed.

3. Heart Health, Blood Pressure, and Cholesterol

Coffee may lower the risk of cardiovascular disease. Caffeinated and decaffeinated coffee both lower the risk, but there are a few differences in how each affects risk factors and outcomes:

  • Decaffeinated coffee is more beneficial for lowering blood pressure.
  • Decaffeinated coffee has more antioxidant and anti-inflammatory effects.
  • Caffeinated coffee is more beneficial for weight management.
  • Caffeinated coffee is more beneficial for preventing arrhythmia (irregular heart rate).

4. Nervousness and Jitteriness 

Drinking caffeinated beverages can make you jittery, jumpy, restless, and nervous. These effects should wear off within a few hours and could last up to 24 hours for some people. The impact is more noticeable with caffeinated coffee than with decaffeinated coffee. 

5. Anxiety and Depression 

While the reasons are not known, moderate coffee consumption—specifically 2 to 3 cups per day—is associated with a lower rate of anxiety and depression. The results are the same for caffeinated and decaffeinated coffee, suggesting that these effects are caused by components of coffee or by lifestyle factors associated with moderate coffee drinking.

6. Headaches 

Caffeine has an impact on headaches. If you don’t regularly consume caffeine, a cup of coffee might make your head pound. But if you skip it when you have gotten used to drinking coffee, the caffeine withdrawal can trigger a headache. 

Caffeinated or decaffeinated coffee can cause headaches or set you up for caffeine withdrawal, and the effects are more intense with caffeinated versions.

7. Gastrointestinal Symptoms

Caffeinated and decaffeinated coffee can both cause stomach upset or diarrhea for some people. But if you’re not having any discomfort when you drink coffee, it’s considered safe for your digestive system.

In fact, moderate coffee consumption of 2 to 4 cups per day has been linked with a lower risk of gastrointestinal disease for people who don’t already have gastrointestinal problems.

8. Weight, Metabolic Syndrome and Diabetes Type 2

Caffeinated and decaffeinated coffee may help prevent weight gain, and that effect has been shown to help lower the risk of metabolic syndrome and diabetes type 2. 

Coffee also counteracts the risk of metabolic syndrome and type 2 diabetes, even beyond weight factor, and the effect is equal for caffeinated and decaffeinated coffee. 

9. Neurological Disorders 

Coffee consumption is associated with a lower risk of neurodegenerative disorders, including Parkinson’s disease and Alzheimer’s disease. Coffee contains many compounds that protect nerves. The neuroprotective effects could help explain how coffee might lower these risks.

10. Cancer 

Many studies have explored the effects of coffee on different types of cancer. So far, there is no clear answer about the impact. Overall, there’s no consistent evidence that coffee could help treat any specific type of cancer or that it causes any specific type of cancer.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Köse Y, Karayigit R, Sertkaya MU. Effects of caffeinated coffee on physical and cognitive performance: Chronotype and time of day study. Chronobiol Int. 2025;42(2):282-296. doi:10.1080/07420528.2025.2460654

  2. Food and Drug Administration. How much caffeine is too much?

  3. Bagheri Davisaraei Y, Nateghi S, Rashidipour H, Raise-Abdullahi P, Rashidy-Pour A. Coffee and sleep: benefits and risks. Prog Brain Res. 2024;288:81-114. doi:10.1016/bs.pbr.2024.06.014

  4. Moura de Araújo MF, Gueiros Gaspar MW, Saraiva Veras V, et al. Consumption of caffeinated and decaffeinated coffee enriched with cocoa and fructo-oligosaccharides among non-diabetic persons: Double blind randomized clinical trial. J Food Biochem. 2022;46(5):e14081. doi:10.1111/jfbc.14081

  5. Colombo R, Papetti A. Decaffeinated coffee and its benefits on health: focus on systemic disorders. Crit Rev Food Sci Nutr. 2021;61(15):2506-2522. doi:10.1080/10408398.2020.1779175

  6. Meamar M, Raise-Abdullahi P, Rashidy-Pour A, Raeis-Abdollahi E. Coffee and mental disorders: How caffeine affects anxiety and depression. Prog Brain Res. 2024;288:115-132. doi:10.1016/bs.pbr.2024.06.015

  7. Haskell-Ramsay CF, Jackson PA, Forster JS, Dodd FL, Bowerbank SL, Kennedy DO. The acute effects of caffeinated black coffee on cognition and mood in healthy young and older adults. Nutrients. 2018;10(10):1386. doi:10.3390/nu10101386

  8. Min J, Cao Z, Cui L, et al. The association between coffee consumption and risk of incident depression and anxiety: Exploring the benefits of moderate intake. Psychiatry Res. 2023;326:115307. doi:10.1016/j.psychres.2023.115307

  9. American Migraine Foundation. Caffeine and migraine.

  10. Alstadhaug KB, Ofte HK, Müller KI, Andreou AP. Sudden caffeine withdrawal triggers migraine—a randomized controlled trialFront Neurol. 2020;11(1):1002. doi:10.3389/fneur.2020.01002

  11. Vitali-Silva A, Bello VA, Poli-Frederico RC, et al. Relationship between food triggers and sensory hypersensitivity in patients with migraine. Relação entre gatilhos alimentares e hipersensibilidade sensorial em pacientes com migrânea. Arq Neuropsiquiatr. 2024;82(11):1-7. doi:10.1055/s-0044-1793934

  12. Iriondo-DeHond A, Uranga JA, del Castillo MD, Abalo R. Effects of coffee and its components on the gastrointestinal tract and the brain–gut axis. Nutrients. 2020;13(1):88. doi: 10.3390/nu13010088

  13. Zhou S, Hu F, Long Z, et al. Coffee consumption and risk of incident gastrointestinal disease: a large prospective cohort study. Food Sci Nutr. 2025;13(12):e71271. doi:10.1002/fsn3.71271

  14. Henn M, Glenn AJ, Willett WC, Martínez-González MA, Sun Q, Hu FB. Changes in coffee intake, added sugar and long-term weight gain – results from three large prospective US cohort studies. Am J Clin Nutr. 2023;118(6):1164-1171. doi:10.1016/j.ajcnut.2023.09.023

  15. Mohamed AI, Erukainure OL, Salau VF, Islam MS. Impact of coffee and its bioactive compounds on the risks of type 2 diabetes and its complications: a comprehensive review. Diabetes Metab Syndr. 2024;18(7):103075. doi:10.1016/j.dsx.2024.103075

  16. Socała K, Szopa A, Serefko A, Poleszak E, Wlaź P. Neuroprotective effects of coffee bioactive compounds: a review. Int J Mol Sci. 2020;22(1):107. doi:10.3390/ijms22010107

  17. Liu M, Song SS, Park S. High polygenic risk scores positively associated with gastric cancer risk interact with coffee and polyphenol intake and smoking status in Korean adults. Nutrients. 2024;16(19):3263. doi:10.3390/nu16193263

  18. Zhang Y, Ma C, Zhao L, Mucci LA, Giovannucci EL. Decaffeinated coffee consumption and risk of total and site-specific cancer. Ann Oncol. 2025;36(7):819-831. doi:10.1016/j.annonc.2025.03.018

Heidi Moawad, MD

By Heidi Moawad, MD

Dr. Moawad is a neurologist and expert in brain health. She regularly writes and edits health content for medical books and publications.