Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017;13:633–43.
Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diab Endocrinol. 2021;9:373–92.
Frydrych LM, Bian G, O’Lone DE, Ward PA, Delano MJ. Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality. J Leukoc Biol. 2018;104:525–34.
Joshi N, Caputo GM, Weitekamp MR, Karchmer AW. Infections in patients with diabetes mellitus. N Engl J Med. 1999;341:1906–12.
Porsche CE, Delproposto JB, Geletka L, O’Rourke R, Lumeng CN. Obesity results in adipose tissue T cell exhaustion. JCI insight. 2021;6:e139793.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, et al. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019;25:141–51.
Lysaght J. The ‘obesity paradox’ in action with cancer immunotherapy. Nat Rev Endocrinol. 2019;15:132–3.
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006;443:350–4.
Barbosa P, Pinho A, Lazaro A, Paula D, Tralhao JG, Paiva A, et al. Bariatric surgery induces alterations in the immune profile of peripheral blood T cells. Biomolecules. 2024;14:219.
Hoseini-Aghdam M, Sheikh V, Eftekharian MM, Rezaeepoor M, Behzad M. Enhanced expression of TIGIT but not neuropilin-1 in patients with type 2 diabetes mellitus. Immunol Lett. 2020;225:1–8.
Lu J, Zhao J, Meng H, Zhang X. Adipose tissue-resident immune cells in obesity and type 2 diabetes. Front Immunol. 2019;10:1173.
Mehta P, Nuotio-Antar AM, Smith CW. gammadelta T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. J Leukoc Biol. 2015;97:121–34.
Li P, Li K, Yuan W, Xu Y, Li P, Wu R, et al. 1alpha,25(OH)(2)D(3) ameliorates insulin resistance by alleviating gammadelta T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression. Theranostics. 2023;13:5290–304.
Costanzo AE, Taylor KR, Dutt S, Han PP, Fujioka K, Jameson JM. Obesity impairs gammadelta T cell homeostasis and antiviral function in humans. PloS one. 2015;10:e0120918.
Pauken KE, Wherry EJ. SnapShot: T cell exhaustion. Cell. 2015;163:1038.e1.
Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15:486–99.
Chen W, Teo JMN, Yau SW, Wong MY, Lok CN, Che CM, et al. Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8(+) T cell exhaustion and curtails anti-PD-1 efficacy. Cell Rep. 2022;41:111647.
Zhang D, Liu G, Ye J, Li K, Zhang G, Quan Q, et al. Low-exhaustion peripheral circulating gammadelta T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or targeted therapy: a single-center retrospective study. BMC Cancer. 2025;25:178.
Garstka MA, Kedzierski L, Maj T. Diabetes can impact cellular immunity in solid tumors. Trends Immunol. 2025;46:295–309.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, Garcia-Canaveras JC, Gassaway BM, et al. Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell. 2020;183:1848–66.e26.
Kivimaki M, Strandberg T, Pentti J, Nyberg ST, Frank P, Jokela M, et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study. Lancet Diab Endocrinol. 2022;10:253–63.
Frydrych LM, Fattahi F, He K, Ward PA, Delano MJ. Diabetes and sepsis: risk, recurrence, and ruination. Front Endocrinol. 2017;8:271.