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Olin, A. et al. Stereotypic immune system development in newborn children. Cell 174, 1277–1292 (2018). Defines conserved postnatal immune cell trajectories in healthy term infants, establishing normative references against which preterm trajectories can be contrasted.
Connors, T. J. et al. Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood. Immunity 56, 1894–1909 (2023). Maps developmental staging of tissue-resident memory T cells across multiple organs, highlighting barrier sites as key early loci of adaptive immune maturation.
Hickman, B. et al. Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants. Nat. Commun. 15, 8323 (2024). Identifies reproducible postnatal gut microbiota maturation trajectories linked to infant health, positioning microbial succession.
Henrick, B. M. et al. Bifidobacteria-mediated immune system imprinting early in life. Cell 184, 3884–3898 (2021).
Park, J. -E. et al. A cell atlas of human thymic development defines T cell repertoire formation. Science 367, eaay3224 (2020). Defines human thymic cellular architecture and T cell repertoire selection during development, establishing a baseline for interpreting neonatal and preterm T cell landscapes.
Gu, W., Eke, C., Santiago, E. G., Olaloye, O. & Konnikova, L. Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells. Mucosal Immunol. 17, 599–617 (2024).
Olaloye, O. et al. A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants. Sci. Transl. Med. 17, eadr0942 (2025). Provides a longitudinal multiomic single-cell atlas of peripheral immunity in extremely premature infants, revealing accelerated yet persistently activated immune programs shaped by prenatal inflammation.
Wang, Y. et al. Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age. Nat. Immunol. 26, 308–322 (2025). Provides a life-cycle-wide single-cell atlas of peripheral immunity, revealing early-life clonal expansions and network remodeling that shape long-term immune composition.
Wells, S. B. et al. Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age. Nat. Immunol. 26, 1612–1625 (2025). Defines tissue-specific immune cell signatures and age-associated alterations across human organs, underscoring that systemic immunological states are shaped by local microenvironments.
Lee, A. H. et al. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. Nat. Commun. 10, 1092 (2019). Technical breakthrough for deriving multi-omic information from small volumes of infant blood enables detection of robust molecular ontogeny across the first 7 days of life, including increases in neutrophil, interferon and complement pathways.
Abel, L. & Casanova, J. -L. Human determinants of age-dependent patterns of death from infection. Immunity 57, 1457–1465 (2024).
Sartoretti, J. & Eberhardt, C. S. The potential role of nonhuman primate models to better comprehend early life immunity and maternal antibody transfer. Vaccines 9, 306 (2021).
Sedney, C. J. & Harvill, E. T. The neonatal immune system and respiratory pathogens. Microorganisms 11, 1597 (2023).
Krangel, M. S., Yssel, H., Brocklehurst, C. & Spits, H. A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J. Exp. Med. 172, 847–859 (1990).
McVay, L. D., Carding, S. R., Bottomly, K. & Hayday, A. C. Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny. EMBO J. 10, 83–91 (1991).
Wu, T. et al. Dynamic regulation of innate lymphoid cell development during ontogeny. Mucosal Immunol. 17, 1285–1300 (2024).
Colonna, M. Innate lymphoid cells: diversity, plasticity, and unique functions in immunity. Immunity 48, 1104–1117 (2018).
Li, N. et al. Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine. J. Exp. Med. 215, 1383–1396 (2018).
Sanchez Sanchez, G., Tafesse, Y., Papadopoulou, M. & Vermijlen, D. Surfing on the waves of the human γδ T cell ontogenic sea. Immunological Rev. 315, 89–107 (2023).
Jung, H. S. et al. SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis. Cell Rep. 34, 108758 (2021).
Yuan, J., Nguyen, C. K., Liu, X., Kanellopoulou, C. & Muljo, S. A. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 335, 1195–1200 (2012).
Cox, G., Kobayashi, M., Rudd, B. D. & Yoshimoto, M. Regulation of HSC development and function by Lin28b. Front. Cell Dev. Biol. 13, 1555877 (2025).
Toothaker, J. M. et al. Immune landscape of human placental villi using single-cell analysis. Development 149, dev200013 (2022).
Brodsky, N. N. et al. Early-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape. Proc. Natl Acad. Sci. USA 122, e2421106122 (2025).
He, S. et al. Systemic immune activity occurs during human immune system maturation. Cell 188, 7291–7308 (2025).
Perez-Muñoz, M. E., Arrieta, M. -C., Ramer-Tait, A. E. & Walter, J. A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome. Microbiome 5, 48 (2017).
Kennedy, K. M. et al. Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature 613, 639–649 (2023).
Wang, W. et al. In utero human intestine contains maternally derived bacterial metabolites. Microbiome 13, 116 (2025).
Li, Y. et al. In utero human intestine harbors unique metabolome, including bacterial metabolites. JCI Insight 5, e138751 (2020).
Mishra, A. et al. Microbial exposure during early human development primes fetal immune cells. Cell 184, 3394–3409 (2021).
Ardeshir, A., Gensollen, T., Zeng, M., Al Nabhani, Z. & Blumberg, R. The Early Life Window of Opportunity: Role of the Microbiome on Immune System Imprinting Vol. 15 (Frontiers Media SA, 2024).
Wessel, R. E. & Dolatshahi, S. Regulators of placental antibody transfer through a modeling lens. Nat. Immunol. 25, 2024–2036 (2024). Synthesizes mechanistic and computational insights into placental IgG transfer, highlighting regulatory checkpoints relevant to passive immunity and premature birth.
Zheng, W. et al. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature 577, 543–548 (2020).
Jennewein, M. F. et al. Fc glycan-mediated regulation of placental antibody transfer. Cell 178, 202–215 (2019).
Twisselmann, N. et al. IgG Fc glycosylation patterns of preterm infants differ with gestational age. Front. Immunol. 9, 3166 (2019).
Erickson, J. J. et al. Pregnancy enables antibody protection against intracellular infection. Nature 606, 769–775 (2022).
Pieren, D. K., Boer, M. C. & de Wit, J. The adaptive immune system in early life: the shift makes it count. Front. Immunol. 13, 1031924 (2022).
Martinez, D. R. et al. Fc characteristics mediate selective placental transfer of IgG in HIV-infected women. Cell 178, 190–201 (2019).
Coler, C. et al. Impact of infections during pregnancy on transplacental antibody transfer. Vaccines 12, 1199 (2024).
Langel, S. N., Blasi, M. & Permar, S. R. Maternal immune protection against infectious diseases. Cell Host Microbe 30, 660–674 (2022).
Crespo, ÂC. et al. Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts. Cell 182, 1125–1139 (2020).
Dzanibe, S. et al. Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants. Nat. Commun. 15, 4080 (2024).
Msallam, R. et al. Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Science 370, 941–950 (2020).
Bao, L. et al. Association analysis of maternal exposure to air pollution during pregnancy and offspring asthma incidence. Reprod. Health 22, 29 (2025).
Brustad, N. et al. Air pollution-induced proteomic alterations increase the risk of child respiratory infections. Nat. Commun. 16, 5930 (2025).
Martino, D. et al. DNA methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life. Nat. Commun. 15, 8167 (2024).
Lim, A. I. et al. Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring. Science 373, eabf3002 (2021).
Hofsink, N. et al. The fetal programming effect of maternal immune activation (MIA) on the offspring’s immune system. Semin. Immunopathol. 46, 14 (2024).
Wang, Z. et al. Recent advances on antimicrobial peptides from milk: Molecular properties, mechanisms, and applications. J. Agric. Food Chem. 72, 80–93 (2023).
Armistead, B. et al. Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination. Mucosal Immunol. 16, 39–49 (2023).
Fang, Z. Y. et al. Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization. Cell Host Microbe 32, 1838–1852 (2024).
Tan, Z. et al. Immune development differs between preterm newborns fed mothers’own milk and donor milk. iScience 28, 112918 (2025).
Bhasin, M. et al. Colostrum as a protective factor against peanut allergy: evidence from a birth cohort. Allergy 81, 552–562 (2025).
Ames, S. R. et al. Human milk feeding practices and serum immune profiles of one-year-old infants in the CHILD birth cohort study. Am. J. Clin. Nutr. 121, 60–73 (2025).
Brodin, P. et al. Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37–47 (2015). Demonstrates that environmental exposures dominate interindividual immune variability, framing early-life experiences as central determinants of immune ontogeny.
Torow, N. et al. M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch. Immunity 56, 1220–1238 (2023).
Stras, S. F. et al. Maturation of the human intestinal immune system occurs early in fetal development. Dev. Cell 51, 357–373 (2019).
Schreurs, R. R. et al. Human fetal TNF-α-cytokine-producing CD4+ effector memory T cells promote intestinal development and mediate inflammation early in life. Immunity 50, 462–476 (2019).
Li, N. et al. Memory CD4+ T cells are generated in the human fetal intestine. Nat. Immunol. 20, 301–312 (2019).
Guo, N. et al. Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation. Nat. Commun. 14, 1318 (2023).
Reitermaier, R. et al. The molecular and phenotypic makeup of fetal human skin T lymphocytes. Development 149, dev199781 (2022).
Gray, J. I. et al. Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span. Sci. Immunol. 9, eadn3954 (2024). Reveals age-dependent and tissue-specific maturation programs of human γδ T cells, highlighting early life as a period of pronounced functional diversification.
Matsumoto, R. et al. Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity. Nat. Immunol. 24, 1370–1381 (2023).
Suo, C. et al. Mapping the developing human immune system across organs. Science 376, eabo0510 (2022). Generates a cross-organ single-cell and spatial map of prenatal immunity, showing system-wide maturation pathways that inform interpretation of postnatal immune trajectories.
Brodin, P. & Davis, M. M. Human immune system variation. Nat. Rev. Immunol. 17, 21–29 (2017). Conceptualizes the immune system as a dynamic, experience-driven network whose variability is shaped over the lifespan by stochastic and environmental forces.
Yost, C. C. et al. Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood 113, 6419–6427 (2009).
Thome, J. J. et al. Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues. Nat. Med. 22, 72–77 (2016).
Gray, J. I. & Farber, D. L. γδ T cells: the first line of defense for neonates. J. Exp. Med. 221, e20240628 (2024).
Thome, J. J. et al. Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell 159, 814–828 (2014). Provides a foundational spatial map showing that T cell phenotypes and maintenance differ dramatically by tissue and age, highlighting the limitations of blood-centric immune profiling.
Senda, T. et al. Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunol. 12, 378–389 (2019).
Mörbe, U. M. et al. Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal Immunol. 14, 793–802 (2021).
Verma, S. et al. Distinct localization, transcriptional profiles, and functionality in early life tonsil regulatory T cells. J. Immunol. 213, 306–316 (2024).
Thapa, P. et al. Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling. Sci. Immunol. 6, eabj0789 (2021).
Zens, K. D. et al. Reduced generation of lung tissue–resident memory T cells during infancy. J. Exp. Med. 214, 2915–2932 (2017).
Rudd, B. D. Neonatal T cells: a reinterpretation. Annu. Rev. Immunol. 38, 229–247 (2020).
Wissink, E. M., Smith, N. L., Spektor, R., Rudd, B. D. & Grimson, A. MicroRNAs and their targets are differentially regulated in adult and neonatal mouse CD8+ T cells. Genetics 201, 1017–1030 (2015).
Szabo, P. A. et al. Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells. Nat. Immunol. https://doi.org/10.1038/s41590-026-02535-1 (2026).
Elahi, S. et al. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature 504, 158–162 (2013).
Pettengill, M. A., van Haren, S. D. & Levy, O. Soluble mediators regulating immunity in early life. Front. Immunol. 5, 457 (2014).
Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A. & Levy, O. Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny. Immunity 46, 350–363 (2017).
Nunez, H. et al. Early life gut microbiome and its impact on childhood health and chronic conditions. Gut Microbes 17, 2463567 (2025).
Pattaroni, C., Marsland, B. J. & Harris, N. L. Early-life host-microbial interactions and asthma development: a lifelong impact? Immunol. Rev. 330, e70019 (2025).
Levy, O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat. Rev. Immunol. 7, 379–390 (2007).
Cerezo-Wallis, D. et al. Architecture of the neutrophil compartment. Nature 649, 1003–1012 (2025).
Sanchez-Schmitz, G. et al. Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model. Sci. Rep. 10, 17836 (2020).
Thind, M. K. et al. A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism. Front. Immunol. 14, 1334205 (2024).
Shouval, D. S. et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity 40, 706–719 (2014).
Koren, O., Konnikova, L., Brodin, P., Mysorekar, I. U. & Collado, M. C. The maternal gut microbiome in pregnancy: implications for the developing immune system. Nat. Rev. Gastroenterol. Hepatol. 21, 35–45 (2024).
Sanidad, K. Z. et al. Gut bacteria-derived serotonin promotes immune tolerance in early life. Sci. Immunol. 9, eadj4775 (2024).
Stevens, J. et al. Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Cell 188, 4239–4256 (2025).
Kelly, M. S. et al. Role of the upper airway microbiota in respiratory virus and bacterial pathobiont dynamics in the first year of life. Nat. Commun. 16, 5195 (2025).
Smilowitz, J. T. et al. Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial. BMC Pediatr. 17, 133 (2017).
Garland, S. M. et al. The ProPrems trial: investigating the effects of probiotics on late onset sepsis in very preterm infants. BMC Infect. Dis. 11, 210 (2011).
Szajewska, H. et al. Technical review by the ESPGHAN special interest group on gut microbiota and modifications on the health outcomes of infant formula supplemented with postbiotics. J. Pediatr. Gastroenterol. Nutr. 82, 235–251 (2025).
Zanobetti, A. et al. ECHO Children’s Respiratory and Environmental Workgroup. Early-life exposure to air pollution and childhood asthma cumulative incidence in the ECHO CREW consortium. JAMA Netw. Open 7, e240535 (2024).
Lei, J. et al. Respiratory benefits of multisetting air purification in children: a cluster randomized crossover trial. JAMA Pediatr. 179, 122–128 (2025).
Carvajal, V. et al. Air pollution and systemic immune biomarkers in early life: a systematic review. Environ. Res. 269, 120838 (2025).
Kampmann, B. & Jones, C. E. Factors influencing innate immunity and vaccine responses in infancy. Philos. Trans. R. Soc. B Biol. Sci. 370, 20140148 (2015).
Levy, O. & Netea, M. G. Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines. Pediatric Res. 75, 184–188 (2014).
Brook, B., Schaltz-Buchholzer, F., Ben-Othman, R., Kollmann, T. & Amenyogbe, N. A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine. Vaccine 40, 1534–1539 (2022).
Brook, B. et al. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. Sci. Transl. Med. 12, eaax4517 (2020).
Robles-Vera, I. et al. Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow. Immunity 58, 381–396 (2025).
Sviridov, D., Netea, M. G. & Bukrinsky, M. I. Maladaptive trained immunity in viral infections. J. Clin. Invest. 135, e192469 (2025).
Male, V. & Jones, C. E. Vaccination in pregnancy to protect the newborn. Nat. Rev. Immunol. 25, 649–661 (2025).
Brophy-Williams, S., Fidanza, M., Marchant, A., Way, S. & Kollmann, T. R. One vaccine for life: lessons from immune ontogeny. J. Paediatr. Child Health 57, 782–785 (2021).
Embleton, N. D. & Berrington, J. E. Milk-based bionutrient trials to improve outcomes in preterm infants: challenges and opportunities. Am. J. Perinatol. 39, S68–S72 (2022).
Lueschow-Guijosa, S. R. et al. Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis. iScience 27, 109993 (2024).
Amodio, D. et al. Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: identifying biomarkers of vaccine responsiveness, respiratory Infections, and asthma. J. Allergy Clin. Immunol. Glob. 4, 100517 (2025).
Levy, O. Vaccinology: getting our modernization act together. J. Exp. Med. 222, e20240961 (2025).
Morrocchi, E., van Haren, S., Palma, P. & Levy, O. Modeling human immune responses to vaccination in vitro. Trends Immunol. 45, 32–47 (2024).
Halkias, J. et al. CD161 contributes to prenatal immune suppression of IFN-γ-producing PLZF+ T cells. J. Clin. Invest. 129, 3562–3577 (2019).
Michaëlsson, J., Mold, J. E., McCune, J. M. & Nixon, D. F. Regulation of T cell responses in the developing human fetus. J. Immunol. 176, 5741–5748 (2006).
Thome, J. J. et al. Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1, eaah6506 (2016).
Pirovano, S. et al. Reconstitution of T-cell compartment after in utero stem cell transplantation: analysis of T-cell repertoire and thymic output. Haematologica 89, 450–461 (2004).
Palmer, D. B. The effect of age on thymic function. Front. Immunol. 4, 316 (2013).
Connors, T. J. et al. Developmental regulation of effector and resident memory T cell generation during pediatric viral respiratory tract infection. J. Immunol. 201, 432–439 (2018).
Semmes, E. C. et al. In utero human cytomegalovirus infection expands NK-like FcγRIII+ CD8+ T cells that mediate Fc antibody functions. J. Clin. Invest. 135, e181342 (2025).
Yu, J. C. et al. Innate immunity of neonates and infants. Front. Immunol. 9, 1759 (2018).
Schlums, H. et al. Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function. Immunity 42, 443–456 (2015).
Kollmann, T. R., Levy, O., Montgomery, R. R. & Goriely, S. Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity 37, 771–783 (2012).
Jalali, S. et al. A high-dimensional cytometry atlas of peripheral blood over the human life span. Immunol. Cell Biol. 100, 805–821 (2022).
Ehlers, G. et al. Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth. Nat. Commun. 16, 2239 (2025).
Makdissi, N. Macrophage development and function. Methods Mol Biol. 2713, 1–9 (2024).
Willems, F., Vollstedt, S. & Suter, M. Phenotype and function of neonatal DC. Eur. J. Immunol. 39, 26–35 (2009).
Zhang, X., Zhivaki, D. & Lo-Man, R. Unique aspects of the perinatal immune system. Nat. Rev. Immunol. 17, 495–507 (2017).
Levy, O. Impaired innate immunity at birth: deficiency of bactericidal/permeability-increasing protein (BPI) in the neutrophils of newborns. Pediatr. Res. 51, 667–669 (2002).
Dhakal, M., Miller, M. M., Zaghouani, A. A., Sherman, M. P. & Zaghouani, H. Neonatal basophils stifle the function of early-life dendritic cells to curtail Th1 immunity in newborn mice. J. Immunol. 195, 507–518 (2015).
Allen, J. E. & Maizels, R. M. Diversity and dialogue in immunity to helminths. Nat. Rev. Immunol. 11, 375–388 (2011).
Grumach, A. S., Ceccon, M. E., Rutz, R., Fertig, A. & Kirschfink, M. Complement profile in neonates of different gestational ages. Scand. J. Immunol. 79, 276–281 (2014).
Strunk, T. et al. Probiotics and antimicrobial protein and peptide levels in preterm infants. Acta Paediatr. 106, 1747–1753 (2017).
O’Brien, C. E. et al. Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants’ gut microbiome. mSphere 11, e00518–25 (2026).
Ziegler, A.-G. et al. Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol. BMJ Open 11, e052449 (2021).
Korpela, K. et al. Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development: a proof-of-concept study. Cell 183, 324–334.e5 (2020).
Wang, H. Z., Hayles, E. H., Fiander, M., Sinn, J. K. & Osborn, D. A. Probiotics in infants for prevention of allergic disease. Cochrane Database Syst. Rev. 6, CD006475 (2025).
Bosheva, M. et al. Infant formula with a specific blend of five human milk oligosaccharides drives the gut microbiota development and improves gut maturation markers: a randomized controlled trial. Front. Nutr. 9, 920362 (2022).
Kruth, S. S. et al. Probiotic supplementation and risk of necrotizing enterocolitis and mortality among extremely preterm infants—the Probiotics in Extreme Prematurity in Scandinavia (PEPS) trial: study protocol for a multicenter, double-blinded, placebo-controlled, and registry-based randomized controlled trial. Trials 25, 259 (2024).
Melsaether, C., Høtoft, D., Wellejus, A., Hermes, G. D. A. & Damholt, A. Seeding the infant gut in early life—effects of maternal and infant seeding with probiotics on strain transfer, microbiota, and gastrointestinal symptoms in healthy breastfed infants. Nutrients 15, 4000 (2023).