Tag: antitumor

Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

Cell lines For macrophages, the RAW 264.7 cell line was purchased from Shanghai Yu Chun ...

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Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA ...

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BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

Mice Male and female C57BL/6J (B6, strain 000664), B6.SJL-Ptprca Pepcb/BoyJ (B6 CD45.1, strain 002014) and ...

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Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

BACH2 overexpression locks T cells in a quiescent ineffective state We and others have shown ...

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PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

The TCF1-PTMA axis maintains mitochondrial homeostasis to sustain CD8 T cell function and preserve immune ...

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CDK10 inhibits innate sensing to constrain antitumor immunity

CDK10 inhibits innate sensing to constrain antitumor immunity

CDK10 inhibits innate sensing to constrain antitumor immunity ...

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CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency

CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency

Cell lines and culture conditions Cell lines used were luciferase-expressing and GFP-expressing Nalm6 (M.S., Columbia ...

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Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy

Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy

Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M. & Reis, E. S. ...

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YTHDF3 suppresses interferon-stimulated gene (ISG)-dependent antitumor immunity and promotes HPV carcinogenesis in cervical cancer

YTHDF3 suppresses interferon-stimulated gene (ISG)-dependent antitumor immunity and promotes HPV carcinogenesis in cervical cancer

Yu R, Zhu B, Chen D. Type I interferon-mediated tumor immunity and its role in ...

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Scarless circular mRNA-based CAR-T cell therapy elicits superior antitumor efficacy

Scarless circular mRNA-based CAR-T cell therapy elicits superior antitumor efficacy

High-yield and scarless cmRNA synthesis via an engineered PIE First, we engineered a new PIE ...

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