Tag: antitumor

The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages

The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, et al. Trained ...

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DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

Xue G, Li X, Kalim M, Fang J, Jiang Z, Zheng N, et al. Clinical ...

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CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off

CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off

Reck, M., Remon, J. & Hellmann, M. D. First-line immunotherapy for non-small-cell lung cancer. J. ...

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TOX drives CD4+ TH1 effector function, antitumor immunity and autoimmune pathology

TOX drives CD4+ TH1 effector function, antitumor immunity and autoimmune pathology

Kaech, S. M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell ...

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Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

Cell lines For macrophages, the RAW 264.7 cell line was purchased from Shanghai Yu Chun ...

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Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA ...

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BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

Mice Male and female C57BL/6J (B6, strain 000664), B6.SJL-Ptprca Pepcb/BoyJ (B6 CD45.1, strain 002014) and ...

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Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

BACH2 overexpression locks T cells in a quiescent ineffective state We and others have shown ...

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PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

The TCF1-PTMA axis maintains mitochondrial homeostasis to sustain CD8 T cell function and preserve immune ...

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CDK10 inhibits innate sensing to constrain antitumor immunity

CDK10 inhibits innate sensing to constrain antitumor immunity

CDK10 inhibits innate sensing to constrain antitumor immunity ...

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