Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy
BACH2 overexpression locks T cells in a quiescent ineffective state We and others have shown ...
The TCF1-PTMA axis maintains mitochondrial homeostasis to sustain CD8 T cell function and preserve immune ...
CDK10 inhibits innate sensing to constrain antitumor immunity ...
Cell lines and culture conditions Cell lines used were luciferase-expressing and GFP-expressing Nalm6 (M.S., Columbia ...
Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M. & Reis, E. S. ...
Yu R, Zhu B, Chen D. Type I interferon-mediated tumor immunity and its role in ...
High-yield and scarless cmRNA synthesis via an engineered PIE First, we engineered a new PIE ...
CD27 agonism enhances vaccine-induced CD4 T cell responses, enabling durable antitumor immunity not entirely dependent ...
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics ...
Hypoxia-induced expression of the zinc-finger transcription factor EGR1 drives immunosuppression in tumor-infiltrating neutrophils. ...