Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution

Class II SCT library enables reliable ex vivo identification of antigen-specific CD4+ T cells We previously ...

CD4+ T cell-mediated immunity protects from VSV-SUD lethal challenge in a mouse model of Sudan virus infection

YF-SUD induces durable protection against lethal VSV-based SUDV GP challenge We first evaluated the protective ...

Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets

Ruterbusch, M., Pruner, K. B., Shehata, L. & Pepper, M. In Vivo CD4(+) T cell ...

TOX drives CD4+ TH1 effector function, antitumor immunity and autoimmune pathology

Kaech, S. M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell ...

Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice

Mice Runx1+/WRPW embryos were generated by incorporation single-strand donor DNA into the Runx1 locus by ...

Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice

GBD 2021 Antimicrobial Resistance Collaborators Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis ...

B cells drive CD4 T cell immunosenescence and age-associated health decline | Science Immunology

B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication ...

Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells

Zitvogel, L., Tesniere, A. & Kroemer, G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat. Rev. ...

CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity | Science Immunology

CD27 agonism enhances vaccine-induced CD4 T cell responses, enabling durable antitumor immunity not entirely dependent ...