Tag: CD8

RUNX phosphorylation specifies CD8+ T cell lineage during positive selection

RUNX phosphorylation specifies CD8+ T cell lineage during positive selection

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B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response

Forte E, Zhang Z, Thorp EB, Hummel M. CytomegalovirUs Latency And Reactivation: An Intricate Interplay ...

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Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice

Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice

Mice Runx1+/WRPW embryos were generated by incorporation single-strand donor DNA into the Runx1 locus by ...

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Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis

Study participants A total of 18 individuals were enrolled in the study—11 with relapsing-remitting MS, ...

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Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA ...

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Publisher Correction: SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer

Publisher Correction: SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer

These authors contributed equally: Lei Wang, Han Chu, Degao Chen, Yuxuan Wei. Department of Oncology, ...

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Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides

Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides

Littman, D. R. How thymocytes achieve their fate. J. Immunol. 196, 1983–1984 (2016). Article  PubMed  ...

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Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling

Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling

Enhanced CD8+ T cell proliferation after temporal cell cycle inhibition To uncouple CD8+ T cell ...

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PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

The TCF1-PTMA axis maintains mitochondrial homeostasis to sustain CD8 T cell function and preserve immune ...

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PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

Klebanoff, C. A. et al. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established ...

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