Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells

Shiravand, Y. et al. Immune checkpoint inhibitors in cancer therapy. Front. Oncol. 12, 1234–1245 (2022). ...

Drug-tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms

Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, et al. Drug-tolerant ...

Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease

BMI1/hypoxia-primed MSC-derived EVs exhibit enhanced immunoregulatory features and alleviate colitis symptoms in vivo To potentiate ...

The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy

Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of ...

Th17-like cells and immunosuppressive macrophages infiltrate tertiary lymphoid structures with distinct maturation status in soft-tissue sarcoma

Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO Classification of Soft Tissue Tumours: ...

Anti-BCMA CAR-T cells attenuate microglial activation in progressive multiple sclerosis: indicating a plasma cell-microglia crosstalk

A recent publication by Qin et al. in Cell reported on the first-in-human application of ...

Anxiety and insomnia linked to sharp drops in key immune cells

Natural killer (NK) cells act as key defenders within the immune system. They help control ...

Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells

Mosquito production Mosquitoes from a colony of Anopheles stephensi (line Nijmegen SDA500) were used to ...

Gene-edited CAR-T cells erase aggressive T-cell leukemia

A new treatment created by scientists at UCL (University College London) and Great Ormond Street ...

Human gut M cells resemble dendritic cells and present gluten antigen

Human specimens and organoid lines Two terminal ileum tissues (donors H0514 and H0515-2) were obtained ...