Sustaining microglial reparative function enhances stroke recovery

Kwakkel, G., Kollen, B. & Twisk, J. Impact of time on improvement of outcome after ...

Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. ...

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

Pharmaceutical chemicals and antibodies N-acetyl-leucine amide (NALA), a competitive antagonist of leucine, was purchased from ...

E3 ubiquitin ligase Stub1 enhances viral replication by promoting TBK1 degradation through molecular chaperone-mediated autophagy

Stub1 negatively regulates type I IFN signaling To assess the effects of Stub1 on RIG-I- ...

Targeting the PSMD14-BCKDK pathway overcomes immune suppression and enhances CAR-NK infiltration in glioblastoma

Tumor cells outcompete NK cells for BCAA, with BCKDK as a key regulator Nutrient competition ...

Targeting NK cell CLEC12B enhances cancer immunotherapy

Lanier, L. L. Five decades of natural killer cell discovery. J. Exp. Med. 221, e20231222 ...

A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors

Fenis, A., Demaria, O., Gauthier, L., Vivier, E. & Narni-Mancinelli, E. New immune cell engagers ...

Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling

Enhanced CD8+ T cell proliferation after temporal cell cycle inhibition To uncouple CD8+ T cell ...

The co-delivery of Programmed Death 1 ligands enhances and prolongs rAAV-mediated gene expression in pre-immunized mice

Plasmids and viral vectors PD-L1-P2A-VEGF-B186 and VEGF-B186-P2A-PD-L1 constructs, with and without codon optimization, were synthesized ...

CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency

Cell lines and culture conditions Cell lines used were luciferase-expressing and GFP-expressing Nalm6 (M.S., Columbia ...