Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells | Science Immunology

Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and ...

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

CXCR4 marks CD4+ memory T cells associated with AML remission To identify features linked to ...

Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. Selective expression of ...

Long COVID involves activation of proinflammatory and immune exhaustion pathways

Proinflammatory pathways are persistently upregulated in LC We evaluated samples from 142 participants who were ...