Targeting the PSMD14-BCKDK pathway overcomes immune suppression and enhances CAR-NK infiltration in glioblastoma

Tumor cells outcompete NK cells for BCAA, with BCKDK as a key regulator Nutrient competition ...

Reprogramming the immune orchestra for glioblastoma: oncolytic viruses and the B-cell connection

Glioblastoma multiforme (GBM) is a lethal primary brain cancer for which treatment has limited options, ...

Targeting hypoxic exosomal IGFBP2 overcomes CD47-mediated immune evasion in glioblastoma

Horbinski C, Berger T, Packer RJ, Wen PY. Clinical implications of the 2021 edition of ...

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity

Louis, D. N. et al. The 2021 WHO Classification of Tumors of the Central Nervous ...