Tag: Lineage

RUNX phosphorylation specifies CD8+ T cell lineage during positive selection

RUNX phosphorylation specifies CD8+ T cell lineage during positive selection

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Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice

Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice

Mice Runx1+/WRPW embryos were generated by incorporation single-strand donor DNA into the Runx1 locus by ...

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Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Human donors BM samples were obtained from three independent cohorts, each used for distinct analyses. ...

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Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides

Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides

Littman, D. R. How thymocytes achieve their fate. J. Immunol. 196, 1983–1984 (2016). Article  PubMed  ...

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BACH2 regulates T cell lineage state to enhance CAR T cell function

BACH2 regulates T cell lineage state to enhance CAR T cell function

Frigault, M. J. et al. Identification of chimeric antigen receptors that mediate constitutive or inducible ...

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Lineage tracing reveals the origins and dynamics of macrophages in lung injury and repair

Lineage tracing reveals the origins and dynamics of macrophages in lung injury and repair

Generation of a CD68-rtTA mouse line for lineage tracing of TRMs To overcome the limitations ...

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