Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species | Science Immunology

Quenching mitochondrial reactive oxygen species in monocyte-derived macrophages, but not in microglia, ameliorates neuroinflammation. ...

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

Pharmaceutical chemicals and antibodies N-acetyl-leucine amide (NALA), a competitive antagonist of leucine, was purchased from ...

Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages

Kurowska-Stolarska M, Alivernini S. Synovial tissue macrophages: friend or foe? RMD Open. 2017;3:e000527. Article  PubMed  ...

Mitochondrial double-stranded RNA drives aging-associated cognitive decline

Walter, P. & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. ...

Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation

Amit, I., Winter, D. R. & Jung, S. The role of the local environment and ...

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

The TCF1-PTMA axis maintains mitochondrial homeostasis to sustain CD8 T cell function and preserve immune ...

5 Ways To Boost Mitochondrial Health, According To A Stanford Scientist

Want more energy & focus? Start here ...

Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment

Study design This study aimed to evaluate whether organelle inheritance controls CD8+ T cell differentiation. ...