Hyperactivation of the cGAS-STING pathway promotes liver inflammation in Down syndrome

Mai CT, Isenburg JL, Canfield MA, Meyer RE, Correa A, Alverson CJ, et al. National ...

Targeting the PSMD14-BCKDK pathway overcomes immune suppression and enhances CAR-NK infiltration in glioblastoma

Tumor cells outcompete NK cells for BCAA, with BCKDK as a key regulator Nutrient competition ...

High-salt diet aggravates allergic rhinitis through the NFAT5 signaling pathway

Wang, X. et al. The traditional Chinese medicine and non-small cell lung cancer: from a ...

A tumour-to-brain pathway hinders anticancer defences

A tumour-to-brain pathway hinders anticancer defences ...

The Overlooked Pathway Connecting Metabolic Health To Brain Aging

Dementia rarely begins with memory loss. Long before names slip or directions blur, subtle changes ...

Gut metabolite indole-3-acetic acid aggravates neuropsychiatric lupus via the AHR/STAT3 pathway in microglia

Crow, M. K. Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets. Ann. Rheum. ...

Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance

GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in ...

Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in bladder cancer

ESM1 was differentially expressed between BC and control tissues We performed immunohistochemistry on 195 internal ...