Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

Study design, patient eligibility and treatment This was a phase 1, first-in-human, open-label, nonrandomized, dose-escalation ...

Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial

Gatto, M., Zen, M., Cruciani, C., Iaccarino, L. & Doria, A. Navigating the landscape of ...

Ipilimumab and nivolumab followed by chemoradiotherapy as bladder-sparing treatment in muscle-invasive bladder cancer: a phase 2 trial

Competing interests M.S.v.d.H. has received institutional funding from Bristol Myers Squibb to finance the INDIBLADE ...

Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial

Study design and treatments Approval Human subject work was performed in accordance with an approved ...

Targeted innate immune inhibition therapy compared with antibiotics for recurrent acute cystitis: a randomized, open-label phase 2 trial

Study design For this randomized, open-label, single-centre, phase 2 trial, patients were enrolled at the ...

Live-attenuated chikungunya vaccine in children: a randomized phase 2 trial

Bartholomeeusen, K. et al. Chikungunya fever. Nat. Rev. Dis. Primers 9, 17 (2023). Article  PubMed  ...

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial

Trial participants Our study population comprised individuals aged 18 years or older with a diagnosis of ...

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial

Oversight The MG-001 part 3 trial was performed in accordance with the principles of the ...

BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial

Preclinical in vitro experiments Generation of CAR cells and evaluation of CAR expression Primary CD8+ ...