Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

PCs are enriched in clinical responders to PD-1 blockade To test the hypothesis that B ...

Transient disruption of T cell help impairs germinal center dynamics and memory responses | Science Immunology

Germinal center responses can recover from transient loss of T cell help, but the sustained ...

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen | Science Immunology

Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust ...

Structural variation tunes apoptotic responses to drive immune escape in melanoma | Science Immunology

Copy-number variation reshapes apoptotic gene dosage to drive acquired immunotherapy resistance in melanoma. ...

Pathogenic IgE-fated memory B cell responses retain functional plasticity | Science Immunology

Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling. ...

CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity | Science Immunology

CD27 agonism enhances vaccine-induced CD4 T cell responses, enabling durable antitumor immunity not entirely dependent ...

Divergent immune responses to commensal bacteria bearing distinct motility signatures | Science Immunology

Motile commensal bacteria that induce immune hyperactivation and colon inflammation are identified. ...

Human OCEL1 senses bacterial infection to unlock inflammatory responses | Science Immunology

Detection of bacteria by human OCEL1 triggers its proteasomal degradation, resulting in increased NF-κB signaling ...

Multi-omics analysis of host airway responses in pediatric Mycoplasma pneumoniae pneumonia reveals potential mechanisms of disease exacerbation caused by co-infection

Demographic characteristics of study participants Considering the prevalence and clinical significance of co-infections with ADV ...

89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4

Mice and cell culture Female Balb/c mice (Jackson Laboratories) were housed and maintained at City ...