SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses

Despite the achievements of immunotherapy in the treatment of cancer, overcoming the immune resistance is ...

A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses

Ethics statement Our research complies with all relevant ethical regulations in accordance with the ethics ...

Maturation-deficient chikungunya virus elicits protective immune responses in a murine challenge model

Since its introduction to the Americas between 2013 and 2014, the CHIKV has become endemic ...

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten

Lnc13 is a candidate regulator of oral gluten tolerance Gliadin peptides from ingested gluten are ...

Social status impacts T-cell responses through synapse strength in the prefrontal cortex

Social status influences T-cell responses to vaccination We used the tube test to determine the ...

DGAT1 mediates sex-specific CD8+ T cell antitumour responses

McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during ...

DNA origami vaccine nanoparticles improve humoral and cellular immune responses to infectious diseases

SQB fabrication SQB fabrication is detailed in a previous publication, including scaffold and staple sequences52,84. ...

COVID-19 boosters restore virus-specific immune responses in kidney transplant recipients unresponsive to primary vaccination

Study design This in-depth immunological analysis was conducted on samples obtained from KTRs selected from ...

Divergent ILC3 responses to PDGF-D control mucosal immunity | Science Immunology

PDGF-D engages PDGFRβ in mice and NKp44 in humans to drive ILC3 responses. ...

Environmental exposure trains the immune system to dampen allergic responses

Environmental exposure trains the immune system to dampen allergic responses ...