The dark side of the dot: How melanosomes dim T cell activity | Science Immunology

Melanoma cells evade immune detection by secreting MHC-peptide–loaded melanosomes that interact with and impair CD8+ ...

Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells | Science Immunology

Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and ...

Immunobiology of the serous cavities | Science Immunology

Local immune function and cross-tissue communication in the serous cavities are reviewed. ...

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells | Science Immunology

Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells ...

B cells drive CD4 T cell immunosenescence and age-associated health decline | Science Immunology

B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication ...

Transient disruption of T cell help impairs germinal center dynamics and memory responses | Science Immunology

Germinal center responses can recover from transient loss of T cell help, but the sustained ...

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen | Science Immunology

Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust ...

When Life Makes Other Plans, Science Can Help You Adapt

Most of us move through life with a quiet assumption that we’re steering the ship. ...

Flossing For Longevity? Science Says It Might Save Your Heart & Brain

If you haven’t listened to your dentist yet, now is the time. ...