CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

CXCR4 marks CD4+ memory T cells associated with AML remission To identify features linked to ...

Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications

Faubert, B., Solmonson, A. & DeBerardinis, R. J. Metabolic reprogramming and cancer progression. Science. 368, ...

Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy

Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M. & Reis, E. S. ...

Rejuvenating the aging gut by targeting senescence

Eskiocak, O. et al. Nat. Aging https://doi.org/10.1038/s43587-025-01022-w (2025). Article  PubMed  Google Scholar  Delgado-Pulido, S., Yousefzadeh, ...

Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease

BMI1/hypoxia-primed MSC-derived EVs exhibit enhanced immunoregulatory features and alleviate colitis symptoms in vivo To potentiate ...

Dual-target CAR-T therapy for ovarian cancer: synergistic targeting of MSLN and B7H3 enhances anti-tumor efficacy and overcomes antigen heterogeneity

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics ...

A T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia

Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis ...