Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory condition with limited treatments. Although macrophages ...

CAR T-cells targeting CD117 effectively eliminate mast cells in preclinical models of advanced systemic mastocytosis

Hoermann G, Sotlar K, Jawhar M, Kristensen T, Bachelot G, Nedoszytko B, et al. Standards ...

Targeting the OTU family: a core therapeutic strategy for reshaping the immunosuppressive microenvironment and reversing drug resistance in HCC by coordinating the autophagy-ferroptosis balance

Hepatocellular carcinoma (HCC) treatment faces dual challenges: resistance to targeted therapy and low response rates ...

Targeting the PSMD14-BCKDK pathway overcomes immune suppression and enhances CAR-NK infiltration in glioblastoma

Tumor cells outcompete NK cells for BCAA, with BCKDK as a key regulator Nutrient competition ...

Targeting NK cell CLEC12B enhances cancer immunotherapy

Lanier, L. L. Five decades of natural killer cell discovery. J. Exp. Med. 221, e20231222 ...

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy

Animals Commercially available 8-week-old T2D mice (db/db mouse, The Jackson Laboratory homozygous BKS.Cg-Dock7m +/+ Leprdb/J, ...

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration

Bellenguez, C. et al. New insights into the genetic etiology of Alzheimer’s disease and related ...

Targeting skull bone marrow hematopoiesis for the treatment of childhood brain tumors

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and ...

Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope

Study participants and collection of clinical samples Large blood draws and leukapheresis samples were collected ...

Targeting hypoxic exosomal IGFBP2 overcomes CD47-mediated immune evasion in glioblastoma

Horbinski C, Berger T, Packer RJ, Wen PY. Clinical implications of the 2021 edition of ...