What Happens to Weight Loss and Muscle Growth When You Take Creatine

What Happens to Weight Loss and Muscle Growth When You Take Creatine

Key Takeaways

  • Creatine is a safe and effective supplement for healthy adults to support muscle growth, exercise performance, and recovery.
  • No current evidence suggests that it directly causes weight or fat loss. However, it can support increased muscle mass, which may lead to higher calorie burning.
  • Because it supports muscle recovery and can increase the energy output in your muscle cells, creatine may lead to more frequent and effective workouts.

Creatine is a well-established supplement for exercise performance and recovery. Although it does not directly impact weight, it may change body composition by improving strength and muscle mass.

How Creatine Affects Muscle Mass and Fat Loss

Taking creatine does not directly lead to weight loss. However, creatine can help support muscle maintenance and growth, which indirectly supports fat loss. Creatine can help aid in fat loss by potentially promoting the following:

  • Increased muscle mass: Muscle mass is active tissue, meaning it burns calories at rest. The more muscle you have, the more calories you burn at rest. Increasing muscle mass may support fat loss when paired with a calorie deficit and other lifestyle factors like regular movement, adequate sleep, and stress management.
  • Improved muscle repair and growth: Creatine increases intracellular water content, which supports muscle growth and repair. It also increases your body’s capacity to create adenosine triphosphate (ATP), or energy for the cell, supporting growth and repair.
  • Increased basal metabolic rate (BMR): Muscle mass is one factor that impacts BMR. Studies show that increasing muscle mass with strength training can slightly increase BMR, which can result in burning more calories at rest. Changes are modest, and this alone may not lead to significant fat loss.
  • Improved exercise performance and recovery: Creatine does not directly impact fat burning during exercise. However, creatine may improve exercise performance and recovery, allowing you to exercise at a higher intensity and more often, which may play a role in fat loss.

How Creatine Affects Exercise Performance

According to the International Society for Sports Nutrition (ISSN), creatine supplementation increases high-intensity exercise performance, may support exercise recovery, and may reduce the risk of injury.

Creatine can support exercise performance by potentially helping with the following:

  • Enhances energy production in your cells: This allows you to exercise at a higher intensity or for a longer time.
  • Increases muscle mass during strength training: When paired with strength training and carbohydrates, creatine can improve strength and muscle mass.
  • Promotes quicker recovery in endurance athletes: For example, creatine has been shown to reduce inflammatory markers and soreness in marathon runners.

Creatine may benefit various workouts, including endurance sports, team sports, and resistance training. It may enhance performance, reduce soreness, and support lean muscle mass, which may play a role in weight loss.

Risks and Side Effects

Creatine is safe for most healthy adults and comes with minimal side effects. However, everyone responds to it differently, and there may be side effects or risks for some people, such as the following:

  • Water retention: Water retention is common with the loading dose of creatine or when taken at high doses. However, it often subsides over time with exercise. Bloating and other digestive issues have been reported with creatine use, but no good evidence to date suggests this is a common side effect.
  • Interactions: Creatine may interact with specific medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen), diuretics, cimetidine, drugs for kidney health, and Probenecid (a treatment for gout).
  • Potential for dehydration or kidney strain in high doses: Some research suggests that creatine may cause dehydration or muscle cramps by redistributing fluids, but no evidence supports this. Studies also show it doesn’t strain or damage the kidneys in healthy adults when taken at recommended doses.

The best way to mitigate side effects is to avoid high doses and stick with the recommended dosing of 3 to 5 grams (g) per day. Though many people take a loading dose, evidence suggests this may be unnecessary. Staying hydrated is also essential.

Who Should Avoid Creatine?

Creatine should be avoided in:

  • Children
  • People who are pregnant or breastfeeding
  • People with kidney disease

Always check with your healthcare provider to determine whether creatine is appropriate for you.

How to Use Creatine for Weight Loss

If you’re taking creatine to lose weight, consider building lean muscle mass through strength training combined with a diet and exercise plan promoting a slight calorie deficit. Here are some tips for using creatine to support weight loss:

  • Dosage: The standard recommended dose for creatine is a loading dose of 20 g per day for seven days and then 3 to 5 g per day following the loading dose for skeletal muscle benefit. Because creatine does not directly contribute to fat loss, there isn’t a standard amount recommended for those with fat loss goals.
  • When to take it: You can take creatine before or after a workout. However, emerging research suggests there may be a slightly greater benefit to taking it after a workout. Consuming carbohydrates, a key macronutrient, along with creatine may also increase creatine uptake into the muscle.
  • How to take it: Though you can mix creatine with water, it may be more palatable when mixed into foods and beverages. You can add it to a smoothie, coffee, or tea or blend it into oatmeal, overnight oats, or energy balls.
  • Supportive fat-loss strategies: Combine creatine with other fat-loss strategies, such as a healthy diet, exercise (e.g., resistance training), adequate sleep, and stress management. Eating in a calorie deficit with adequate protein to support muscle maintenance and satiety is also essential.

Creatine may be one tool you include on your weight-loss journey, but on its own, it will not lead to weight loss. It is essential to combine it with other fat-loss strategies, such as an effective workout program and diet.

In the United States, the Food and Drug Administration (FDA) does not regulate dietary supplements the way it regulates prescription medications. As a result, some supplement products may not contain the ingredients listed on the label. 

When choosing a supplement, look for products independently tested or certified by organizations such as NSF, U.S. Pharmacopeia, or ConsumerLab.com. For personalized guidance, consult your healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Forbes SC, Candow DG, Krentz JR, et al. Changes in fat mass following creatine supplementation and resistance training in adults ≥50 years of age: a meta-analysis. J Funct Morphol Kinesiol. 2019;4(3):62. Published 2019 Aug 23. doi:10.3390/jfmk4030062

  2. Aristizabal JC, Freidenreich DJ, Volk BM, et al. Effect of resistance training on resting metabolic rate and its estimation by a dual-energy X-ray absorptiometry metabolic mapEur J Clin Nutr. 2015;69(7):831-836. doi:10.1038/ejcn.2014.216

  3. Wu SH, Chen KL, Hsu C, et al. Creatine supplementation for muscle growth: a scoping review of randomized clinical trials from 2012 to 2021. Nutrients. 2022;14(6):1255. Published 2022 Mar 16. doi:10.3390/nu14061255

  4. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18. Published 2017 Jun 13. doi:10.1186/s12970-017-0173-z

  5. National Center for Complementary and Integrative Health. Body building and performance enhancement supplements: what you need to know.

  6. Candow DG, Ostojic SM, Forbes SC, Antonio J. Does one dose of creatine supplementation fit all? Adv Exerc Health Sci. 2024;1(2):99-107. doi:10.1016/j.aehs.2024.05.002

  7. MedlinePlus. Creatine.

  8. Ribeiro F, Longobardi I, Perim P, et al. Timing of creatine supplementation around exercise: a real concern? Nutrients. 2021;13(8):2844. Published 2021 Aug 19. doi:10.3390/nu13082844

  9. Xenaki N, Bacopoulou F, Kokkinos A, et al. Impact of a stress management program on weight loss, mental health and lifestyle in adults with obesity: a randomized controlled trial. J Mol Biochem. 2018;7(2):78-84.

  10. Papatriantafyllou E, Efthymiou D, Zoumbaneas E, et al. Sleep deprivation: effects on weight loss and weight loss maintenance. Nutrients. 2022;14(8):1549. Published 2022 Apr 8. doi:10.3390/nu14081549

  11. Moon J, Koh G. Clinical evidence and mechanisms of high-protein diet-induced weight loss. J Obes Metab Syndr. 2020;29(3):166-173. doi:10.7570/jomes20028

Sarah Anzlovar Verywell Health

By Sarah Anzlovar, MS, RD

Sarah is a private-practice registered dietitian nutritionist with a Master’s in Nutrition Communication from the Tufts University Friedman School of Nutrition Science and Policy. She completed her dietetics training at Brigham and Women’s Hospital, a teaching hospital of Harvard University.