CAR T-cells targeting CD117 effectively eliminate mast cells in preclinical models of advanced systemic mastocytosis

Hoermann G, Sotlar K, Jawhar M, Kristensen T, Bachelot G, Nedoszytko B, et al. Standards ...

Low-dose radiotherapy synergizes with PD-1 blockade to achieve durable survival in advanced NSCLC through antitumor neutrophil programming

Durable survival with TRIDENT in treatment-naïve advanced NSCLC In our prospective phase I clinical trial ...

Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

Study design, patient eligibility and treatment This was a phase 1, first-in-human, open-label, nonrandomized, dose-escalation ...

Talking to Your Adult Children About Your Advanced Parkinson

When talking to your adult children about advanced Parkinson’s, you can share some basic information ...

Diagnosed With Advanced Renal Cell Carcinoma: Why You May Want a Second Opinion, and How to Find One

Seeking out a second opinion can give you the confidence that you’re getting the best ...

Physical Activity for Advanced Parkinson’s: Why and How to Stay Active

If you want to lessen your Parkinson’s symptoms through physical activity, include aerobic exercise, strengthening, ...

Strategies to Reduce Fall Risk in Advanced Parkinson’s

Your healthcare provider can help you lower your fall risk by addressing medications and other ...

Freezing in Advanced Parkinson’s Disease: Why It Happens and How You Can Get Moving Again

To treat freezing episodes, your healthcare provider will want to know how often they happen ...

Oncolytic viruses: advanced strategies in cancer therapy

Kaufman, H. L., Kohlhapp, F. J. & Zloza, A. Oncolytic viruses: a new class of ...

How to Manage Anxiety in Advanced Parkinson

If you notice increased anxiety with Parkinson’s disease, you can try several lifestyle changes and ...