Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. ...

LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity

The success of therapeutic cancer vaccines hinges on overcoming the immunosuppressive tumor microenvironment (TME) and ...

Low-dose radiotherapy synergizes with PD-1 blockade to achieve durable survival in advanced NSCLC through antitumor neutrophil programming

Durable survival with TRIDENT in treatment-naïve advanced NSCLC In our prospective phase I clinical trial ...

Citraconate preserves T cell stemness and antitumor immunity | Science Immunology

Citraconate preserves stemness, mitigates ferroptosis, and potentiates T cell antitumor immunity by modulating the PDE1-cAMP-ALOX5 ...

De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy

Baulu E, Gardet C, Chuvin N, Depil S. TCR-engineered T cell therapy in solid tumors: ...

The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, et al. Trained ...

DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

Xue G, Li X, Kalim M, Fang J, Jiang Z, Zheng N, et al. Clinical ...

CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off

Reck, M., Remon, J. & Hellmann, M. D. First-line immunotherapy for non-small-cell lung cancer. J. ...

TOX drives CD4+ TH1 effector function, antitumor immunity and autoimmune pathology

Kaech, S. M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell ...

Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

Cell lines For macrophages, the RAW 264.7 cell line was purchased from Shanghai Yu Chun ...