Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory condition with limited treatments. Although macrophages ...

CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease

Liver inflammation is a key driver of nonalcoholic fatty liver disease (NAFLD) and its progressive ...

Mechanistic impasses: tofacitinib treatment ameliorates GM-CSF-driven macrophage inflammation

Satoeya N, Zack SR, Zoubi OA, Umar S, Burgos A, Abdulrab S, et al. Tofacitinib ...

Chemokine-defined macrophage niches establish spatial organization of tumor immunity

RecMacs display protumor transcriptional signatures To identify macrophage subsets associated with tumor regression or progression, ...

An ontogeny-cytokine code determines macrophage response polarity and tumor outcomes

Noy, R. & Pollard, J. W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49–61 ...

A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors

Fenis, A., Demaria, O., Gauthier, L., Vivier, E. & Narni-Mancinelli, E. New immune cell engagers ...

ANGPTL2 inhibits macrophage pyroptosis and alleviates rheumatoid arthritis progression by regulating mitophagy via IGFBP5

Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388:2023–38. Google Scholar  Alivernini S, Firestein ...

RETN exacerbates sepsis by GBP5/NLRP3 signaling pathway-mediated pyroptosis of macrophage

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The ...

Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation

Amit, I., Winter, D. R. & Jung, S. The role of the local environment and ...

STING controls glycolysis and histone lactylation to drive macrophage metabolic reprogramming in postoperative ileus

Vather, R., Trivedi, S. & Bissett, I. Defining postoperative ileus: results of a systematic review ...