Tag: Tcell

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

Pharmaceutical chemicals and antibodies N-acetyl-leucine amide (NALA), a competitive antagonist of leucine, was purchased from ...

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Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Ticks and saliva collection Rhipicephalus microplus ticks (Porto Alegre strain, free from Babesia spp. and ...

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Social status impacts T-cell responses through synapse strength in the prefrontal cortex

Social status impacts T-cell responses through synapse strength in the prefrontal cortex

Social status influences T-cell responses to vaccination We used the tube test to determine the ...

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DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling

DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling

Cells and ethics The cell lines were purchased from ATCC (Manassas, VA) and cultured in ...

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Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response

Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response

Meier P, Legrand AJ, Adam D, Silke J. Immunogenic cell death in cancer: targeting necroptosis ...

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B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response

Forte E, Zhang Z, Thorp EB, Hummel M. CytomegalovirUs Latency And Reactivation: An Intricate Interplay ...

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A T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia

A T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia

Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis ...

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Gene-edited CAR-T cells erase aggressive T-cell leukemia

Gene-edited CAR-T cells erase aggressive T-cell leukemia

A new treatment created by scientists at UCL (University College London) and Great Ormond Street ...

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Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control

Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control

Ledergor G, Fan Z, Wu K, McCarthy E, Hyrenius-Wittsten A, Starzinski A, et al. CD4+ ...

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