Metabolic adaptations of immunosuppressive cells in cancer: mechanisms and therapeutic targets

Swanton, C. et al. Embracing cancer complexity: hallmarks of systemic disease. Cell 187, 1589–1616 (2024). ...

Targeting the OTU family: a core therapeutic strategy for reshaping the immunosuppressive microenvironment and reversing drug resistance in HCC by coordinating the autophagy-ferroptosis balance

Hepatocellular carcinoma (HCC) treatment faces dual challenges: resistance to targeted therapy and low response rates ...

Mechanisms and therapeutic potential of colchicine in atherosclerotic cardiovascular disease

Ross, R. Atherosclerosis–an inflammatory disease. N. Engl. J. Med. 340, 115–126 (1999). Established the paradigm ...

CD70/CD27 signaling promotes the pathogenesis of multiple myeloma and represents a promising therapeutic target

Vogelsberg A, Schürch CM, Fend F. Multiples Myelom aus Sicht der Pathologie. Radiologe. 2022;62:12–19. Article  ...

Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets

Ruterbusch, M., Pruner, K. B., Shehata, L. & Pepper, M. In Vivo CD4(+) T cell ...

Immuno-molecular features and therapeutic implications of brain metastases in clear cell renal cell carcinoma patients

We start with a case report, because it illustrates well the current challenges and possibilities ...

Th17/Treg cell imbalance in allergic rhinitis: mechanisms and therapeutic implications

Siddiqui ZA, Walker A, Pirwani MM, Tahiri M, Syed I. Allergic rhinitis: diagnosis and management. ...

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

Park, M. D., Silvin, A., Ginhoux, F. & Merad, M. Macrophages in health and disease. ...

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration

Bellenguez, C. et al. New insights into the genetic etiology of Alzheimer’s disease and related ...

7 Best Medical and Therapeutic Interventions for Acute Pain

Acute pain can be hard to ignore. It often comes on suddenly and is intense, ...