Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. ...

LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity

The success of therapeutic cancer vaccines hinges on overcoming the immunosuppressive tumor microenvironment (TME) and ...

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

Pharmaceutical chemicals and antibodies N-acetyl-leucine amide (NALA), a competitive antagonist of leucine, was purchased from ...

Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity

Bianconi, E. et al. An estimation of the number of cells in the human body. ...

Citraconate preserves T cell stemness and antitumor immunity | Science Immunology

Citraconate preserves stemness, mitigates ferroptosis, and potentiates T cell antitumor immunity by modulating the PDE1-cAMP-ALOX5 ...

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Ticks and saliva collection Rhipicephalus microplus ticks (Porto Alegre strain, free from Babesia spp. and ...

CD4+ T cell-mediated immunity protects from VSV-SUD lethal challenge in a mouse model of Sudan virus infection

YF-SUD induces durable protection against lethal VSV-based SUDV GP challenge We first evaluated the protective ...

Chemokine-defined macrophage niches establish spatial organization of tumor immunity

RecMacs display protumor transcriptional signatures To identify macrophage subsets associated with tumor regression or progression, ...

Venezuelan equine encephalitis virus: novel live-attenuated vaccines for inducing complete protective immunity

Forrester, N. L. et al. Evolution and spread of Venezuelan equine encephalitis complex alphavirus in ...

Improved VSV-Ebola-GP booster vaccination approach promotes antibody affinity maturation and durable anti-Ebola immunity in humans

Delayed booster vaccination with rVSV∆G-ZEBOV-GP at 18 months promotes durable EBOV-neutralizing antibodies Longitudinal antibody repertoire ...