Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery

Selection of TCRs The 16 disease-derived TCRs analyzed in this study were previously obtained and ...

Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution

Class II SCT library enables reliable ex vivo identification of antigen-specific CD4+ T cells We previously ...

Multi-omics profiling reveals tumor microenvironment characteristics linked to immunotherapy response and prognosis in non-small cell lung cancer

Elevated CD8 + T cell infiltration correlates with enhanced immune reactivity The graphic abstract of this study ...

Spatial profiling uncovers multicellular dynamics in early relapse of hepatitis B virus-associated follicular lymphoma

Cartron, G. & Trotman, J. Time for an individualized approach to first-line management of follicular ...

Gonococcal outer membrane vesicle vaccines: bacterial population biology, clinical trials, immune profiling, and vaccine design

Quillin, S. J. & Seifert, H. S. Neisseria gonorrhoeae host adaptation and pathogenesis. Nat. Rev. ...

Metabolomic profiling reveals alterations in Candida pathophysiology and host interactions during primary oral candidiasis and following antifungal treatment

Millsop, J. W. & Fazel, N. Oral candidiasis. Clin. Dermatol. 34, 487–494 (2016). PubMed  Google ...

Immune profiling in a living human recipient of a gene-edited pig kidney

Kidney xenotransplantation and sample collection An EGEN-2784 gene-edited pig kidney was transplanted into a 62-year-old ...

Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in bladder cancer

ESM1 was differentially expressed between BC and control tissues We performed immunohistochemistry on 195 internal ...