Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment

a 2 × 105 strongly acidic tumor cells (B16F10) were inoculated into the right flank of Gpr65-deficient ...

Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

Study design, patient eligibility and treatment This was a phase 1, first-in-human, open-label, nonrandomized, dose-escalation ...

Application of CAR-T therapy in solid tumors: current opportunities and challenges

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global ...

A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors

Fenis, A., Demaria, O., Gauthier, L., Vivier, E. & Narni-Mancinelli, E. New immune cell engagers ...

OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours

Vivier, E., Tomasello, E., Baratin, M., Walzer, T. & Ugolini, S. Functions of natural killer ...

Anti-MSLN chimeric antigen receptor-like NK cell therapy with tumor-penetrating capacity (uCAR-like NK) for solid tumors

Construction and characterization of the bispecific cell engager MSLN×CD16A To construct the bispecific cell engager ...