WASH regulates B cell signaling, metabolism and function through STAT1

WASH regulates B cell signaling, metabolism and function through STAT1

  • Papa R, Penco F, Volpi S, Gattorno M. Actin remodeling defects leading to autoinflammation and immune dysregulation. Front Immunol. 2020;11:604206.

  • Lappalainen P, Kotila T, Jégou A, Romet-Lemonne G. Biochemical and mechanical regulation of actin dynamics. Nat Rev Mol Cell Biol. 2022;23:836–52.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, et al. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci USA. 2010;107:10442–7.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, et al. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013;32:2685–96.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119–34.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Johnson JL, Meneses-Salas E, Ramadass M, Monfregola J, Rahman F, Carvalho Gontijo R, et al. Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation. Nat Commun. 2022;13:5529.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, et al. Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS ONE. 2014;9:e98606.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Piotrowski JT, Gomez TS, Schoon RA, Mangalam AK, Billadeau DD. WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol. 2013;33:958–73.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Clark DN, Begg LR, Filiano AJ. Unique aspects of IFN-γ/STAT1 signaling in neurons. Immunol Rev. 2022;311:187–204.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Ding H, Wang G, Yu Z, Sun H, Wang L. Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway. Biomed Pharmacother. 2022;155:113683.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Yuan C, Qi J, Zhao X, Gao C. Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation. J Biol Chem. 2012;287:17006–15.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Guo X, Ma P, Li Y, Yang Y, Wang C, Xu T, et al. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death Differ. 2021;28:640–56.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Kang YH, Biswas A, Field M, Snapper SB. STAT1 signaling shields T cells from NK cell-mediated cytotoxicity. Nat Commun. 2019;10:912.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Raja R, Wu C, Bassoy EY, Rubino TE, Jr., Utagawa EC, Magtibay PM, et al. PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling. J Immunother Cancer. 2022;10:e005026.

  • Tolomeo M, Cavalli A, Cascio A. STAT1 and its crucial role in the control of viral infections. Int J Mol Sci. 2022;23:4095.

  • Meissl K, Macho-Maschler S, Müller M, Strobl B. The good and the bad faces of STAT1 in solid tumours. Cytokine. 2017;89:12–20.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Domeier PP, Chodisetti SB, Soni C, Schell SL, Elias MJ, Wong EB, et al. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med. 2016;213:715–32.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Xu W, Zhang JJ. Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation. J Immunol. 2005;175:7419–24.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Vandsemb EN, Rye MB, Steiro IJ, Elsaadi S, Rø TB, Slørdahl TS, et al. PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2. FEBS J. 2021;288:6700–15.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Dong Y, Yu C, Ma N, Xu X, Wu Q, Lu H, et al. MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis. Mol Biomed. 2022;3:25.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Jiang Y, Zhuang Z, Jia W, Wen Z, Xie M, Bai H, et al. Proteomic and phosphoproteomic analysis reveal threonine deficiency increases hepatic lipid deposition in Pekin ducks via reducing STAT phosphorylation. Anim Nutr. 2023;13:249–60.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Cariappa A, Tang M, Parng C, Nebelitskiy E, Carroll M, Georgopoulos K, et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity. 2001;14:603–15.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Bai X, Zhang Y, Huang L, Wang, J, Li, W, Niu, L, et al. The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 downregulation. Blood. 1997;128:1723–34.

  • Gerasimcik N, Westerberg LS, Severinson E. Methods to study the role of Cdc42, Rac1, and Rac2 in B-cell cytoskeletal responses. Methods Mol Biol. 2018;1821:235–46.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Burbage M, Keppler SJ, Gasparrini F, Martínez-Martín N, Gaya M, Feest C, et al. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. J Exp Med. 2015;212:53–72.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, et al. Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton. Cell. 2016;164:433–46.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, et al. Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. Cell Death Dis. 2017;8:e3063.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gomes LC, Di Benedetto G, Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol. 2011;13:589–98.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Giacomello M, Pyakurel A, Glytsou C, Scorrano L. The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol. 2020;21:204–24.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Haan C, Rolvering C, Raulf F, Kapp M, Drückes P, Thoma G, et al. Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors. Chem Biol. 2011;18:314–23.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Chen X, Zhu M, Zou X, Mao Y, Niu J, Jiang J, et al. CCL2-targeted ginkgolic acid exerts anti-glioblastoma effects by inhibiting the JAK3-STAT1/PI3K-AKT signaling pathway. Life Sci. 2022;311:121174.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Muhlethaler-Mottet A, Di Berardino W, Otten LA, Mach B. Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. Immunity. 1998;8:157–66.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Ramana CV, Grammatikakis N, Chernov M, Nguyen H, Goh KC, Williams BR, et al. Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J. 2000;19:263–72.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS, Stephanou A. STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem. 2004;279:5811–20.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Génin P, Morin P, Civas A. Impairment of interferon-induced IRF-7 gene expression due to inhibition of ISGF3 formation by trichostatin A. J Virol. 2003;77:7113–9.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tisserand J, Khetchoumian K, Thibault C, Dembélé D, Chambon P, Losson R. Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition. J Biol Chem. 2011;286:33369–79.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, et al. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012;119:3966–74.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, et al. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012;119:2819–28.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Verboon JM, Rincon-Arano H, Werwie TR, Delrow JJ, Scalzo D, Nandakumar V, et al. Wash interacts with lamin and affects global nuclear organization. Curr Biol. 2015;25:804–10.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Descatoire M, Fritzen R, Rotman S, Kuntzelman G, Leber XC, Droz-Georget S, et al. Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification. Cell Rep. 2022;38:110474.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Sereni L, Castiello MC, Marangoni F, Anselmo A, di Silvestre D, Motta S, et al. Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation. J Allergy Clin Immunol. 2018;142:1272–84.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Li N, Jiang P, Chen A, Luo X, Jing Y, Yang L, et al. CX3CR1 positively regulates BCR signaling coupled with cell metabolism via negatively controlling actin remodeling. Cell Mol Life Sci. 2020;77:4379–95.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Zhu Y, Gu H, Yang L, Li N, Chen Q, Kang D, et al. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2. Clin Transl Med. 2022;12:e887.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Yu T, Li X, Luo Q, Liu H, Jin J, Li S, et al. S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation. Life Sci Alliance 2023;6:e202201623.

  • Li L, Xin B, Kuang W, Zhou Z, Huang ZL. Divide and conquer: real-time maximum likelihood fitting of multiple emitters for super-resolution localization microscopy. Opt Express. 2019;27:21029–49.

    Article 
    PubMed 

    Google Scholar
     

  • Wu C, Kuang WB, Zhou ZW, Zhang YJ, Huang ZL. FACAM: a fast and accurate clustering analysis method for protein complex quantification in single molecule localization microscopy. Photonics. 2023;10:427.

  • Liu Y, Han R, Zhou L, Luo M, Zeng L, Zhao X, et al. Comparative performance of the GenoLab M and NovaSeq 6000 sequencing platforms for transcriptome and LncRNA analysis. BMC Genom. 2021;22:829.

    Article 
    CAS 

    Google Scholar
     

  • Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol. 2012;13:R16.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Yu G, Wang LG, He QY. ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics. 2015;31:2382–3.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Jiang P, Jing Y, Zhao S, Lan C, Yang L, Dai X, et al. Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease. Nat Commun. 2024;15:2627.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Han H, Cho JW, Lee S, Yun A, Kim H, Bae D, et al. TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Res. 2018;46:D380–6.

    Article 
    PubMed 
    CAS 

    Google Scholar