SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses

Despite the achievements of immunotherapy in the treatment of cancer, overcoming the immune resistance is ...

Local oxygen tension dictates hematopoietic cell growth and potency

Hematopoietic cells from differently oxygenated niches exhibit distinct properties Each hematopoietic niche exists at different ...

Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. ...

Multi-omics profiling reveals tumor microenvironment characteristics linked to immunotherapy response and prognosis in non-small cell lung cancer

Elevated CD8 + T cell infiltration correlates with enhanced immune reactivity The graphic abstract of this study ...

Hematological and immune cell changes in complete blood count before and after hemodialysis

The majority of this study’s cohort were middle-aged (40–60 years old) with hypertension as the predominant ...

Calibrating T cell responsiveness through interactions with self

Klein, L. & Petrozziello, E. Antigen presentation for central tolerance induction. Nat. Rev. Immunol. 25, ...

Epidermal MHC-II-mediated NK cell recruitment triggers keratinocyte pyroptosis, facilitating pathogenesis of psoriasis

MHC-II is highly expressed in psoriatic skin lesions First, our scRNA-seq analysis of epidermal samples ...

A differentiated effector T cell repertoire defines a functionally high-risk group of smoldering myeloma patients

A differentiated effector T cell repertoire defines a functionally high-risk group of smoldering myeloma patients ...

Foxp3: The epigenetic engineer of regulatory T cell identity | Science Immunology

The Foxp3 transcription factor integrates cell-intrinsic and environmental contexts with epigenetic programs to establish regulatory ...