Immune System

Adding weekly GLP-1 to cognitive behavioral therapy further reduces heavy drinking

Adding weekly GLP-1 to cognitive behavioral therapy further reduces heavy drinking

Thursday, April 30, 2026 Clinical trial suggests semaglutide may help patients with alcohol use disorder and obesity. A team of ...

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Ticks and saliva collection Rhipicephalus microplus ticks (Porto Alegre strain, free from Babesia spp. and Anaplasma spp.) were obtained from ...

Cytosolic CTH senses bacterial lipoproteins and drives noncanonical inflammasome activation

Cytosolic CTH senses bacterial lipoproteins and drives noncanonical inflammasome activation

Kawai, T., Ikegawa, M., Ori, D. & Akira, S. Decoding Toll-like receptors: recent insights and perspectives in innate immunity. Immunity ...

Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation

Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation

IBD–UC increased colonic crypt TCRγδ+STAT5+ T cells Using FACS analysis, we examined PBMCs from n = 24 UC, n = 21 Crohn’s disease and ...

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten

Lnc13 is a candidate regulator of oral gluten tolerance Gliadin peptides from ingested gluten are presented by antigen-presenting cells on ...

Long-lived immune cells show promise against cancer in world-first trial

Long-lived immune cells show promise against cancer in world-first trial

Conventional CAR T cells (purple and yellow spheres; artificially coloured) attack a cancer cell.Credit: Steve Gschmeissner/Science Photo Library The first ...

Short-, medium-, versus long-chain fatty acids: mechanisms of immunomodulation and disease pathogenesis

Short-, medium-, versus long-chain fatty acids: mechanisms of immunomodulation and disease pathogenesis

Kim CH. Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids. Cell Mol Immunol. 2021;18:1161–71. Article  CAS  PubMed  PubMed ...

Machine learning in prediction and classification of type 1 diabetes

Machine learning in prediction and classification of type 1 diabetes

Machine learning in prediction and classification of type 1 diabetes ...

De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy

De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy

Baulu E, Gardet C, Chuvin N, Depil S. TCR-engineered T cell therapy in solid tumors: state of the art and ...

First-ever 3D view shows how killer T cells destroy cancer

First-ever 3D view shows how killer T cells destroy cancer

Cytotoxic T lymphocytes act as the immune system’s specialized “killer” cells, seeking out and eliminating infected or cancerous cells with ...