In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Science Immunology

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming. ...

CAR T-cells targeting CD117 effectively eliminate mast cells in preclinical models of advanced systemic mastocytosis

Hoermann G, Sotlar K, Jawhar M, Kristensen T, Bachelot G, Nedoszytko B, et al. Standards ...

Metabolic adaptations of immunosuppressive cells in cancer: mechanisms and therapeutic targets

Swanton, C. et al. Embracing cancer complexity: hallmarks of systemic disease. Cell 187, 1589–1616 (2024). ...

Defining the rules of engagement: B cells, antibodies and cancer control

Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination ...

Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity

Bianconi, E. et al. An estimation of the number of cells in the human body. ...

B cells gone broad: A deep dive into SARS-CoV-2 antibody breadth | Science Immunology

Antigen-specific B cell profiling uncovers key determinants of SARS-CoV-2 antibody breadth after infection and vaccination. ...

Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation

IBD–UC increased colonic crypt TCRγδ+STAT5+ T cells Using FACS analysis, we examined PBMCs from n = 24 ...

Long-lived immune cells show promise against cancer in world-first trial

Conventional CAR T cells (purple and yellow spheres; artificially coloured) attack a cancer cell.Credit: Steve ...

First-ever 3D view shows how killer T cells destroy cancer

Cytotoxic T lymphocytes act as the immune system’s specialized “killer” cells, seeking out and eliminating ...