Tag: Cells

BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

Mice Male and female C57BL/6J (B6, strain 000664), B6.SJL-Ptprca Pepcb/BoyJ (B6 CD45.1, strain 002014) and ...

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Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury

Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury

de Perrot, M., Liu, M., Waddell, T. K. & Keshavjee, S. Ischemia-reperfusion-induced lung injury. Am. ...

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PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells | Science Immunology

The TCF1-PTMA axis maintains mitochondrial homeostasis to sustain CD8 T cell function and preserve immune ...

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Ferroptotic tumour cells inhibit dendritic cell maturation through GPX4 release

Ferroptotic tumour cells inhibit dendritic cell maturation through GPX4 release

All forms of cancer therapy — including immunotherapy, chemotherapy and radiotherapy — rely to some ...

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PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

Klebanoff, C. A. et al. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established ...

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Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models

Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models

Collier DA, Ferreira IATM, Kotagiri P, Datir RP, Lim EY, Touizer E, et al. Age-related ...

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Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells

Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells

Zitvogel, L., Tesniere, A. & Kroemer, G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat. Rev. ...

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A New Study Links Stress With Lower Levels Of Key Immune Cells

A New Study Links Stress With Lower Levels Of Key Immune Cells

For years, “stress makes you sick” was thought of more as a wellness cliché than ...

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Inflammatory stress-induced amino acid transformation generates diabetogenic T cells

Inflammatory stress-induced amino acid transformation generates diabetogenic T cells

Inflammatory stress-induced amino acid transformation generates diabetogenic T cells ...

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tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells

tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells

Mice Trmt61afl/fl mice were constructed using the CRISPR-Cas9-based genome-editing system by inserting two loxP sites ...

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