Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment

a 2 × 105 strongly acidic tumor cells (B16F10) were inoculated into the right flank of Gpr65-deficient ...

Activation of CD40 in tumors reprograms the tumor microenvironment

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Multi-omics profiling reveals tumor microenvironment characteristics linked to immunotherapy response and prognosis in non-small cell lung cancer

Elevated CD8 + T cell infiltration correlates with enhanced immune reactivity The graphic abstract of this study ...

Targeting the OTU family: a core therapeutic strategy for reshaping the immunosuppressive microenvironment and reversing drug resistance in HCC by coordinating the autophagy-ferroptosis balance

Hepatocellular carcinoma (HCC) treatment faces dual challenges: resistance to targeted therapy and low response rates ...

Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

Study design, patient eligibility and treatment This was a phase 1, first-in-human, open-label, nonrandomized, dose-escalation ...

Single-cell transcriptomics reveals heterogeneity and immune microenvironment in lymphatic metastasis of head and neck squamous cell carcinoma

Qin Y, Zheng X, Gao W, Wang B, Wu Y. Tumor microenvironment and immune-related therapies ...

Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist

Hopfner KP, Hornung V. Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol ...

Metabolites as signalling molecules in the tumour immune microenvironment

Mao, Y. & Jiang, P. The crisscross between p53 and metabolism in cancer. Acta Biochim. ...

The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy

Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of ...

Intraperitoneal immune microenvironment and efficacy of intraperitoneal chemotherapy in patients with gastric cancer and peritoneal metastasis

Our previous study demonstrated that intraperitoneal paclitaxel improves survival outcomes in patients with gastric cancer ...