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This is a summary of: Steeghs, N. et al. Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study. Nat. Cancer https://doi.org/10.1038/s43018-026-01150-1 (2026).