Activation of CD40 in tumors reprograms the tumor microenvironment

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Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

Study design, patient eligibility and treatment This was a phase 1, first-in-human, open-label, nonrandomized, dose-escalation ...

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Ticks and saliva collection Rhipicephalus microplus ticks (Porto Alegre strain, free from Babesia spp. and ...

PD-1 blockade reprograms antiviral immunity and reduces the HIV reservoir

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Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury

de Perrot, M., Liu, M., Waddell, T. K. & Keshavjee, S. Ischemia-reperfusion-induced lung injury. Am. ...

A microbiota-dependent bile acid reprograms alveolar macrophages to control lung inflammation

The human microbiota orchestrates immune responses through both local cell-cell interactions and circulating metabolites. While ...

Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses

Ethical compliance All research described in this study was conducted in accordance with relevant institutional ...