Telegram iComsium Current root: /home/u514654129/domains/awesamohealth.com/public_html/wp-content/themes/pixwell
Current path: /home/u514654129/domains/awesamohealth.com/public_html/wp-content/themes/pixwell
..
404.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
archive-gallery.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
archive-portfolio.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
archive.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
assets
author.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
backend
category.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
comments.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
footer.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
functions.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
header.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
includes
index.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
languages
page-bookmark.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
page.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
plugins
screenshot.png | [Göster] | [Düzenle] | [Yeniden Adlandır]
search.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
single-gallery.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
single-portfolio.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
single.php | [Göster] | [Düzenle] | [Yeniden Adlandır]
style.css | [Göster] | [Düzenle] | [Yeniden Adlandır]
templates
woocommerce
wpml-config.xml | [Göster] | [Düzenle] | [Yeniden Adlandır]

Dosya Yükle

PARK7-induced delactylation of ATAD3A impairs mitochondrial fitness to promote exhaustion of tumor-infiltrating CD8+ T cells - Awesamo Health

PARK7-induced delactylation of ATAD3A impairs mitochondrial fitness to promote exhaustion of tumor-infiltrating CD8+ T cells

PARK7-induced delactylation of ATAD3A impairs mitochondrial fitness to promote exhaustion of tumor-infiltrating CD8+ T cells

  • Blank CU, et al. Defining ‘T cell exhaustion. Nat Rev Immunol. 2019;19:665–74. https://doi.org/10.1038/s41577-019-0221-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chow A, Perica K, Klebanoff CA, Wolchok JD. Clinical implications of T-cell exhaustion for cancer immunotherapy. Nat Rev Clin Oncol. 2022;19:775–90. https://doi.org/10.1038/s41571-022-00689-z.

    Article 
    PubMed 

    Google Scholar
     

  • Franco F, Jaccard A, Romero P, Yu YR, Ho PC. Metabolic and epigenetic regulation of T-cell exhaustion. Nat Metab. 2020;2:1001–12. https://doi.org/10.1038/s42255-020-00280-9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wherry EJ. T-cell exhaustion. Nat Immunol. 2011;12:492–9. https://doi.org/10.1038/ni.2035.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Im SJ, Ha SJ. Redefining T-cell exhaustion: subset, function, and regulation. Immune Netw. 2020;20:e2. https://doi.org/10.4110/in.2020.20.e2.

    Article 
    PubMed 

    Google Scholar
     

  • Gounari F, Khazaie K. TCF-1: a maverick in T-cell development and function. Nat Immunol. 2022;23:671–8. https://doi.org/10.1038/s41590-022-01194-2.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhao X, Shan Q, Xue HH. TCF1 in T-cell immunity: a broadened frontier. Nat Rev Immunol. 2022;22:147–57. https://doi.org/10.1038/s41577-021-00563-6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Scott AC, et al. TOX is a critical regulator of tumor-specific T-cell differentiation. Nature. 2019;571:270–4. https://doi.org/10.1038/s41586-019-1324-y.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Khan O, et al. TOX transcriptionally and epigenetically programs CD8(+) T-cell exhaustion. Nature. 2019;571:211–8. https://doi.org/10.1038/s41586-019-1325-x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen J, et al. NR4A transcription factors limit CAR T-cell function in solid tumors. Nature. 2019;567:530–4. https://doi.org/10.1038/s41586-019-0985-x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Scharping NE, et al. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T-cell exhaustion. Nat Immunol. 2021;22:205–15. https://doi.org/10.1038/s41590-020-00834-9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Soto-Heredero G, Desdin-Mico G, Mittelbrunn M. Mitochondrial dysfunction defines T-cell exhaustion. Cell Metab. 2021;33:470–2. https://doi.org/10.1016/j.cmet.2021.02.010.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Baldwin JG, et al. Intercellular nanotube-mediated mitochondrial transfer enhances T-cell metabolic fitness and antitumor efficacy. Cell. 2024;187:6614–30 e6621. https://doi.org/10.1016/j.cell.2024.08.029.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rackham O, Filipovska A. Organization and expression of the mammalian mitochondrial genome. Nat Rev Genet. 2022;23:606–23. https://doi.org/10.1038/s41576-022-00480-x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Falkenberg M, Larsson NG, Gustafsson CM. Replication and Transcription of Human Mitochondrial DNA. Annu Rev Biochem. 2024;93:47–77. https://doi.org/10.1146/annurev-biochem-052621-092014.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kukat C, Larsson NG. mtDNA makes a U-turn for the mitochondrial nucleoid. Trends Cell Biol. 2013;23:457–63. https://doi.org/10.1016/j.tcb.2013.04.009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Matilainen O, Quiros PM, Auwerx J. Mitochondria and epigenetics – crosstalk in homeostasis and stress. Trends Cell Biol. 2017;27:453–63. https://doi.org/10.1016/j.tcb.2017.02.004.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • He J, et al. The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol. 2007;176:141–6. https://doi.org/10.1083/jcb.200609158.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bogenhagen DF, Rousseau D, Burke S. The layered structure of human mitochondrial DNA nucleoids. J Biol Chem. 2008;283:3665–75. https://doi.org/10.1074/jbc.M708444200.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • He J, et al. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Res. 2012;40:6109–21. https://doi.org/10.1093/nar/gks266.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Waak J, et al. Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1. FASEB J. 2009;23:2478–89. https://doi.org/10.1096/fj.08-125153.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang X, et al. Parkinson’s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J Neurochem. 2012;121:830–9. https://doi.org/10.1111/j.1471-4159.2012.07734.x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Giaime E, et al. Loss of function of DJ-1 triggered by Parkinson’s disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ. 2010;17:158–169. https://doi.org/10.1038/cdd.2009.116.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lee JY, et al. Human DJ-1 and its homologs are novel glyoxalases. Hum Mol Genet. 2012;21:3215–3225. https://doi.org/10.1093/hmg/dds155.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bonifati V, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003;299:256–259. https://doi.org/10.1126/science.1077209.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Danileviciute E, et al. PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during aging. Nat Metab. 2022;4:589–607. https://doi.org/10.1038/s42255-022-00576-y.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ishihara T, Ban-Ishihara R, Ota A, Ishihara N. Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation. Proc Natl Acad Sci USA. 2022;119:e2210730119. https://doi.org/10.1073/pnas.2210730119.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Arguello T, et al. ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly. Cell Rep. 2021;37:110139. https://doi.org/10.1016/j.celrep.2021.110139.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Brar KK, et al. PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress. Science. 2024;385:eadp7114. https://doi.org/10.1126/science.adp7114.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xie XQ, et al. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria. Cell Res. 2023;33:215–228. https://doi.org/10.1038/s41422-022-00766-z.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hong H, et al. ABCF1-K430-Lactylation promotes HCC malignant progression via transcriptional activation of HIF1 signaling pathway. Cell Death Differ. 2025;32:613–631. https://doi.org/10.1038/s41418-024-01436-w.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang Z, et al. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma. Nat Metab. 2023;5:61–79. https://doi.org/10.1038/s42255-022-00710-w.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kouzarides T. Chromatin modifications and their function. Cell. 2007;128:693–705. https://doi.org/10.1016/j.cell.2007.02.005.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vardhana SA, et al. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nat Immunol. 2020;21:1022–1033. https://doi.org/10.1038/s41590-020-0725-2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu YR, et al. Disturbed mitochondrial dynamics in CD8(+) TILs reinforce T-cell exhaustion. Nat Immunol. 2020;21:1540–1551. https://doi.org/10.1038/s41590-020-0793-3.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Imberechts D, Vandenberghe W. Defects in PINK-PRKN-PARK7/DJ-1-dependent mitophagy and autosomal recessive Parkinson disease. Autophagy. 2023;19:1872–1873. https://doi.org/10.1080/15548627.2022.2139129.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang B, et al. Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7. Autophagy. 2016;12:1215–1228. https://doi.org/10.1080/15548627.2016.1179401.

    Article 
    CAS 
    PubMed 

    Google Scholar